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Oxidative challenge in Alzheimer's disease: state of knowledge and future needs

Carlo Cervellati, Paul L Wood, Arianna Romani, Giuseppe Valacchi, Monica Squerzanti, Juana Maria Sanz, Beatrice Ortolani, Giovanni Zuliani
DOI: 10.1136/jim-2015-000017 Published 11 January 2016
Carlo Cervellati
1Department of Biomedical and Specialist Surgical Sciences, Section of Medical Biochemistry, Molecular Biology and Genetics University of Ferrara, Ferrara, Italy
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Paul L Wood
2Metabolomics Unit, Math and Science Building, Lincoln Memorial University, Harrogate, Tennessee, USA
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Arianna Romani
1Department of Biomedical and Specialist Surgical Sciences, Section of Medical Biochemistry, Molecular Biology and Genetics University of Ferrara, Ferrara, Italy
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Giuseppe Valacchi
3Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy
4Department of Food and Nutrition, Kyung Hee University, Seoul, South Korea
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Monica Squerzanti
1Department of Biomedical and Specialist Surgical Sciences, Section of Medical Biochemistry, Molecular Biology and Genetics University of Ferrara, Ferrara, Italy
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Juana Maria Sanz
5Department of Medical Science, Section of Internal and CardioRespiratory Medicine, University of Ferrara, Ferrara, Italy
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Beatrice Ortolani
5Department of Medical Science, Section of Internal and CardioRespiratory Medicine, University of Ferrara, Ferrara, Italy
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Giovanni Zuliani
5Department of Medical Science, Section of Internal and CardioRespiratory Medicine, University of Ferrara, Ferrara, Italy
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Abstract

A large body of experimental and postmortem findings indicate that Alzheimer's disease (AD) is associated with increased oxidative stress (OxS) levels in the brain. Despite the current limitations of OxS assessment in living subjects, recent data suggest that oxidative challenge might increase early both in the central nervous system and peripheral fluids. The aim of this review was to provide an overview of the existing literature linking systemic OxS to brain OxS in AD. We firmly believe that continued research aimed at overcoming the methodological and design issues affecting the body of studies in this field is mandatory for successful development of an effective antioxidant-based treatment of AD.

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Vol 64 Issue 1 Table of Contents
Journal of Investigative Medicine: 64 (1)
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Oxidative challenge in Alzheimer's disease: state of knowledge and future needs
Carlo Cervellati, Paul L Wood, Arianna Romani, Giuseppe Valacchi, Monica Squerzanti, Juana Maria Sanz, Beatrice Ortolani, Giovanni Zuliani
Journal of Investigative Medicine Jan 2016, 64 (1) 21-32; DOI: 10.1136/jim-2015-000017

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Oxidative challenge in Alzheimer's disease: state of knowledge and future needs
Carlo Cervellati, Paul L Wood, Arianna Romani, Giuseppe Valacchi, Monica Squerzanti, Juana Maria Sanz, Beatrice Ortolani, Giovanni Zuliani
Journal of Investigative Medicine Jan 2016, 64 (1) 21-32; DOI: 10.1136/jim-2015-000017
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Oxidative challenge in Alzheimer's disease: state of knowledge and future needs
Carlo Cervellati, Paul L Wood, Arianna Romani, Giuseppe Valacchi, Monica Squerzanti, Juana Maria Sanz, Beatrice Ortolani, Giovanni Zuliani
Journal of Investigative Medicine Jan 2016, 64 (1) 21-32; DOI: 10.1136/jim-2015-000017
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  • Article
    • Abstract
    • Background
    • AD: diagnosis and neuropathological features
    • OxS: an imbalance leading to biological damage
    • Involvement of OxS in AD pathogenesis
    • OxS and AD: from theory to practical applications
    • Conclusions
    • Footnotes
    • References
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  • eLetters
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