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Western Regional Meeting 2016, Carmel, California, January 28–30, 2016

DOI: 10.1136/jim-d-15-00013.226 Published 11 January 2016
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  • Abstract 227 Figure 1
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    Abstract 227 Figure 1

    (A) Representative images and quantification of (B) MBP+ or (C) Nk×2.2+ cells following exposure to PGE2. (D) Expression of PGE2 receptors in OPCs. (E) Images and (F) quantification of MBP+ cells from EP1−/− and control mice exposed to PGE2.

  • Abstract 233 Figure 1
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    Abstract 233 Figure 1
  • Abstract 325 Figure 1
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    Abstract 325 Figure 1

    Scatter plot showing relationship of PDL1 expression (percent of image pixels positive) and CD4 lymphocyte infiltration (as measured by percent image pixels positive) in HNSCC.

  • Abstract 359 Figure 1
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    Abstract 359 Figure 1
  • Abstract 366 Figure 1
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  • Abstract 376 Figure 1
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    Abstract 376 Figure 1

Tables

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  • Abstract 230 Table 1
    Study WeekWeight (kg)Height (cm)Waist Circ. (cm)BMI-%ileTBF (%)FFM (%)
    Week 081.9±24.6157.7±7.1104.1±15.794.8±10.028.1±7.771.8±7.8
    Week 2477.8±24.0158.7±7.1103.6±14.792.3±12.426.0±8.774.1±8.7
    p-value< 0.001<0.0010.640.01<0.001<0.001
  • Abstract 239 Table 1
    VMC Sub-population
    αα
    CNTL (n=14)
    <3%
    Heart Failure (n=10)
    <3%
    ββ61% +/–17%83% +/–11%**
    αβ30% +/–19%7% +/–5%**
  • Abstract 241 Table 1
    EndpointsECMO to VAD to OHT (n=10)ECMO to OHT (n=4)Log Rank
    P-Value
    1-Year Actuarial Survival90.0%50.0%0.068
    1-Year Actuarial Freedom from CAV66.7%25.0%0.295
    1-Year Actuarial from NF-MACE85.7%100.0%0.593
    1-Year Actuarial Freedom from Any Treated Rejection90.0%100.0%0.507
    • P=NS.

  • Abstract 242 Table 1
    EndpointsGroup A
    No Anti-HTN Medication
    (n=30)
    Group B
    1 Anti-HTN Medication
    (n=30)
    Group C
    2 Anti-HTN Medications
    (n=56)
    Group D
     ≥ 3 Anti-HTN Medications
    (n=24)
    P-Value
    3-Year Actuarial Survival100.00%89.80%84.10%91.70%0.592
    3-Year Actuarial Freedom from CAV88.20%95.80%80.20%79.30%0.261
    3-Year Actuarial Freedom from NF-MACE100.00%96.70%86.80%100.00%0.067
    1-Year Actual Freedom from Any Treated Rejection93.30%90.00%77.60%86.20%0.398
    1-Year Actual Freedom from Antibody Mediated Rejection96.70%93.30%96.40%100.00%0.631
    1-Year Actual Freedom from Acute Cellular Rejection93.30%96.70%86.80%91.00%0.636
    1-Year Actual Freedom from Biopsy Negative Rejection100.00%100.00%90.70%95.20%0.194
    Interventricular Septal Thickness (IVS) > 1.2 cm10.0% (3/30)13.3% (4/30)16.1% (9/56)16.7% (4/24)P=NS
    Left Ventricular Posterior Wall (LVPW) > 1.2 cm3.3% (1/30)6.7% (2/30)7.1% (4/56)8.3% (2/24)P=NS
    • P=NS.

  • Abstract 246 Table 1
    Study WeekLDL Chol(mg/dl)HDL Chol(mg/dl)TG(mg/dl)BMI-%ileFFM(%)A1c(%)
    Week 097±2036±8172±8995±1071.8±7.85.9±0.7
    Week 2479±1742±9106±4792±1274.1±8.75.6±0.5
    p-value<0.0001<0.001<0.0001<0.05<0.001<0.001
  • Abstract 247 Table 1
    Statistical DataA1CGlycomarkAgeDiabetes DurationBMIMean 24h GlucoseMean Glucose excursionGender
    Slope7.77–1.490.450.44–2.110.160.15NA
    R-Squared0.020.030.060.030.090.030.03NA
    p value0.440.340.140.320.060.320.330.86
  • Abstract 254 Table 1

    ARE Detection Performance by TCM, mCAP, Respiratory Rate and Pulse-oximetry

    Total ARE132
    Mean ARE per minute detected by each modality
    TCM0.065/minute
    Capnography0.179/minute
    Respiratory Rate0.003/minute
    Pulse-oximetry0.019/minute
  • Abstract 263 Table 1

    Models for prediction of survival without BPD

    Full cohort (n=507)Genetic cohort (n=414)
    OR(95% CI)P valueOR(95% CI)P valueOR(95% CI)P value
    AFR ancestry2.6(1.4, 4.8)0.002
    AA2.0(1.3, 3.2)0.0032.6(1.5, 4.4)0.0004
    Hispanic1.2(0.6, 2.5)0.551.7(0.8, 3.6)0.19
    Other1.8(0.7, 4.5)0.192.4(0.9, 6.6)0.08
    Birth weight1.0(1.0, 1.0)0.011.0(1.0, 1.0)0.0041.0(1.0, 1.0)0.005
    Birth weight centile1.0(1.0, 1.0)0.941.0(1.0, 1.0)0.611.0(1.0, 1.0)0.59
    Male sex0.4(0.3, 0.7)0.00040.4(0.3, 0.7)0.0010.4(0.2, 0.7)0.0003
    Multiple gestation1.1(0.7, 1.8)0.621.2(0.7, 2.0)0.411.2(0.7, 2.0)0.46
    RSS (MAPxFiO2) at study entry0.7(0.6, 0.8)<0.00010.7(0.6, 0.8)<0.00010.7(0.6, 0.8)<0.0001
  • Abstract 273 Table1

    % Mortality for Each Group as a Function of CS Dose, mg/g (LD50=2.25)

    1.01.52.03.04.0
    WtWtWtHetWt+HemeWtWt
    0.0% (n=17)8.3% (n=12)40.9% (n=22)75.0% (n=12)6.3% (n=32)75.0% (n=20)100.0% (n=6)
  • Abstract 274 Table1

    Fold Change in HO Activity Over Control (VVV). (*p<0.05 vs VHH)

    VVVVHHZL-HHZBG-HH
    Liver1.0±0.2 (n=8)1.7±0.3 (n=15)1.5±0.2* (n=11)1.4±0.3*(n=12)
    Spleen1.0±0.3 (n=6)1.5±0.3 (n=4)1.4±0.2 (n=4)1.1±0.2* (n=4)
  • Abstract 277 Table 1
    HourspHHCO3-(mEq/L)Mean BP
    (mmHg)
    Urine Output
    (mL/Kg/h)
    1–127.290±0.08121.7±1.352±311.1±5.4
    13–247.399±0.13423.9±1.347±74.4±3.1
    25–367.267±0.07422.9±1.450±84.9±6.0
    37–487.199±0.12921.7±3.148±83.6±3.2
    49–607.248±0.04820.0±0.534±40.9±0.8
    61–727.018±0.01018.6±0.136±10.6±0.1
  • Abstract 287 Table 1

    Statistically significant outcomes upon ERAS application in 11 studies

    Length of StayComplicationsReadmitsCost
    Improved11311
    Not Improved/reported081010
    Total11111111
  • Abstract 287 Table 2

    Proposed ERAS pathway for plastic surgery

    PreoperativeIntraoperativePostoperative
    –Pre–admission patient counseling & education
    –Minimize starvation/dehydration
    –DVT and antibiotic prophylaxis
    –Preoperative warming
    –Multimodal prophylactic analgesia
    –Opioid–sparing anesthetic regimen
    –Best surgical techniques
    –Euvolemia
    –Antiemetics
    –Minimize drains
    –Intraoperative warming
    –Postoperative warming
    –Early mobilization
    –Wound care
    –Early resumption of oral hydration and diet
    –Multimodal analgesia with opioids for breakthrough pain
  • Abstract 288 Table 1
    MonthsIEHP Charge CaptureAll Other Charge CaptureP-Values
    Jan 2013-Jun 201311.07%25.95%0.001114
    Jul 2013-Dec 201313.66%26.65%0.0003675
    Jan 2014-Jun 201414.52%27.77%7.89E–06
    Jul 2014-Dec 201415.17%29.24%3.69E–05
  • Abstract 289 Table 1

    Results

    OutcomesCorrectly Predicted ComplicationsAverage Predicted Risk in Study Population (n=104)Actual Incidence in Practice (n=4924)
    Serious Complication14 (20.9)6.3%67 (1.4)
    Any Complication73 (78.5)8.7%93 (1.9)
    Surgical Site Infection10 (24.4)3.3%10 (0.2)
    Venous Thromboembolism00.4%1 (0.0)
    Return to OR14 (24.1)4.9%58 (1.2)
  • Abstract 290 Table 1

    Patient Demographics

    PatientAgeCervicomental Classification Scale ScoreDose in mL (10 mg / 1 mL)Pain ScoreAdjunctive Treatments
    1482.253.43Cheek volume augmentation*
    2391.753.62Fat grafting**
    3412.755.64None
    • *Patient 1 underwent treatment with Juvéderm Voluma XC (Allergan, CA USA) in the malar region three weeks prior to injection.

    • **Patient 2 underwent autologous fat grafting to her mid-face five months prior to injection.

  • Abstract 311 Table 1

    Breakdown of Colleges

    Colleges AttendingURM (n=88)Non-URM (n=275)P Value
    UC46.00%45.80%0.90
    Ivy League1.10%4.40%0.56
    Top 204.60%6.90%0.62
    Cal State8.00%4.00%0.15
    2 Year College16.00%1.80%0.0001
    Other23.90%37.10%N/A
    • “Top 20” was obtained from USA news' nationwide university ranking.

  • Abstract 337 Table 1

    Intracellular HO-1-Expression in Blood and Spleen Immune Cells (MFI±SEM)

    Blood HO-1NPRPRLPS-PRp
    Neutrophils7048±16145276±260#7777±434##0.0006
    Monocytes5996±5275256±243#10383±602##< 0.0001
    MHC II+ DCs8999±1329*5393±281*#11360±552#*0.0241, #0.0001
    Spleen HO-1
    Neutrophils3347±10622843±2053115±138ns
    Monocytes3387±9812968±211#0.0±0.0##< 0.0001
    DCs8089±11006488±7086992±180ns
  • Abstract 347 Table 1
    Epo (N=24)Placebo (N=26)P value
    Severe encephalopathy21%15%0.72
    In hospital mortality2 (8%)5 (19%)0.47
    6 month WIDEA75.3 (SD 9.0)69.0 (SD 11.0)0.04
    MRI–normal8 (36%)3 (12%)0.01
    MRI–mild injury13 (59%)11 (44%)
    MRI–moderate injury1 (5%)6 (24%)
    MRI–severe injury0 (0%)5 (20%)
  • Abstract 350 Table 1

    Maternal and Neonatal Demographics and Outcomes

    Insulin N=61Non-insulin N=69P- value
    Birth weight, g*613±150786±149< 0.001
    Gestational age, wks.*25.1±1.627±2.7< 0.001
    Chorioamnionitis–N (%)26 (42.6)20 (29)0.11
    PIH–N (%)27 (44.3)22 (31.9)0.15
    Antenatal Steroids–N. (%)56 (91.8)64 (92.8)0.61
    Advanced resuscitation atbirth–N. (%)29 (47.5)17 (24.6)0.005
    Vaginal delivery–N (%)12 (19.7)7 (10.2)0.13
    Mortality–N (%)11 (18.3)5 (7.3)0.062
    Severe IVH–N (%)6 (9.8)3 (4.4)0.21
    Severe ROP–N (%)23 (37.7)7 (10.2)< 0.001
    BPD–N (%)40 (65.6)38 (55.1)0.014
    • *Mean±SD.

  • Abstract 351 Table 1
    Risk on TB Nomogram
    ETCOc (ppm; median; IQR)
    ETCOc <1.01.0≤ ETCOc ≤1.51.5< ETCOc <2.5ETCOC >2.5
    TB<40th %tile (n=18)
    ETCOc (1.3; 1.1–1.6)
    4 (22%)9 (50%)5 (28%)0 (0%)
    TB=40th to 75th %tile (n=34)
    ETCOc (1.2; 1.1–1.7)
    3 (9%)19 (56%)12 (35%)0 (0%)
    TB>75 ≤ 95th %tile (n=25)
    ETCOc (1.8; 1.4–2.0)
    0 (0%)9 (36%)14 (56%)2 (8%)
    TB>95th %tile (n=4)
    ETCOc (2.7; 2.4–3.0)
    0 (0%)0 (0%)1 (25%)3 (75%)
    Total (n=82)7 (9%)38 (47%)32 (40%)5 (6%)
  • Abstract 368 Table 1
    ProcedureNumber
    Delayed breast reconstruction with tissue expanders, bilateral serratus anterior muscle flap5
    Delayed reconstruction of bilateral breasts with breast implants under TRAM1
    Breast reduction4
    Cheek fasciocutaneous flap for skin cancer reconstruction2
    Finger flexor tendon tenolysis3
    Thumb CMC joint arthroplasty1
    Split thickness skin graft5
    Harvest of skin graft from right leg and skin graft to right and left axillae measuring 430 cm21
  • Abstract 369 Table 1

    Facial Edema and Redness Rating Scale

    Pigmentation (Bruising)RednessTurgor (from edema)Swelling (Height)
    0, no bruising0, none0, normal0, normal
    1, slight bruising1, light to pink1, supple1, <2 mm
    2, moderate bruising2, pink to red2, yielding2, 2–5 mm
    3, heavy bruising3, red3, firm3, >5 mm
    4, vivid red4, hard
  • Abstract 371 Table 1

    Spider Silk vs. Suture Stress Comparison

    SampleFiber Stress (St. Dev.)Knot Stress (St. Dev.)
    MaSp1/MaSp2 12 Fiber Thread147.43 MPa (29.64)166.93 MPa (12.21)
    6–0 Vicryl Suture368.33 MPa (37.77)180.88 MPa (11.14)
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Western Regional Meeting 2016, Carmel, California, January 28–30, 2016
Journal of Investigative Medicine Jan 2016, 64 (1) 232-299; DOI: 10.1136/jim-d-15-00013.226

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Journal of Investigative Medicine Jan 2016, 64 (1) 232-299; DOI: 10.1136/jim-d-15-00013.226
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Journal of Investigative Medicine Jan 2016, 64 (1) 232-299; DOI: 10.1136/jim-d-15-00013.226
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    • Joint Plenary Session, WAFMR, WSCI, WAP AND WSPR, 8:00 AM
    • Adolescent Medicine and General Pediatrics II, Concurrent Session, 12:30 PM
    • Cardiovascular III, Concurrent Session
    • Endocrinology and Metabolism II, Concurrent Session
    • Gastroenterology, Concurrent Session
    • Genetics, Concurrent Session
    • Neonatal Pulmonary III, Concurrent Session
    • Neonatology General III, Concurrent Session
    • Neonatology Perinatal Biology I, Concurrent Session
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    • Infectious Diseases II, Concurrent Session
    • Morphogenesis and Malformations, Concurrent Session
    • Neonatology General IV, Concurrent Session
    • Nephrology and Hypertension, Concurrent Session
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