Protein signaling and regulation of gene transcription in leukemia: role of the Casein Kinase II-Ikaros axis
Chandrika S Gowda, Chunhua Song, Yali Ding, Malika Kapadia, Sinisa Dovat
DOI: 10.1136/jim-2016-000075 Published 24 February 2016
Chandrika S Gowda
Department of Pediatrics, Penn State University College of Medicine, Hershey, Pennsylvania, USA
Chunhua Song
Department of Pediatrics, Penn State University College of Medicine, Hershey, Pennsylvania, USA
Yali Ding
Department of Pediatrics, Penn State University College of Medicine, Hershey, Pennsylvania, USA
Malika Kapadia
Department of Pediatrics, Penn State University College of Medicine, Hershey, Pennsylvania, USA
Sinisa Dovat
Department of Pediatrics, Penn State University College of Medicine, Hershey, Pennsylvania, USA
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Protein signaling and regulation of gene transcription in leukemia: role of the Casein Kinase II-Ikaros axis
Chandrika S Gowda, Chunhua Song, Yali Ding, Malika Kapadia, Sinisa Dovat
Journal of Investigative Medicine Mar 2016, 64 (3) 735-739; DOI: 10.1136/jim-2016-000075
- Article
- Abstract
- Introduction
- Structure and biologic function of Ikaros
- Role of Ikaros as a tumor suppressor in leukemia
- Phosphorylation of Ikaros by CK2 controls Ikaros activity
- Dephosphorylation of Ikaros by protein phosphatase 1
- Phosphorylation regulates stability of Ikaros protein
- CK2 and PP1 Regulate Ikaros-mediated repression of TdT and cellular proliferation in leukemia
- Targeting CK2-Ikaros pathway in B cell Leukemia
- Conclusion
- Acknowledgments
- Footnotes
- References
- Figures & Data
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