Fine-tuning patient-derived xenograft models for precision medicine approaches in leukemia
Olivia L Francis, Terry-Ann M Milford, Cornelia Beldiman, Kimberly J Payne
DOI: 10.1136/jim-2016-000076 Published 24 February 2016
Olivia L Francis
1Department of Pathology and Human Anatomy, Center for Health Disparities and Molecular Medicine, Loma Linda University School of Medicine, Loma Linda, California, USA
Terry-Ann M Milford
2Department of Basic Sciences, Center for Health Disparities and Molecular Medicine, Loma Linda University School of Medicine, Loma Linda, California, USA
Cornelia Beldiman
1Department of Pathology and Human Anatomy, Center for Health Disparities and Molecular Medicine, Loma Linda University School of Medicine, Loma Linda, California, USA
Kimberly J Payne
1Department of Pathology and Human Anatomy, Center for Health Disparities and Molecular Medicine, Loma Linda University School of Medicine, Loma Linda, California, USA
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Fine-tuning patient-derived xenograft models for precision medicine approaches in leukemia
Olivia L Francis, Terry-Ann M Milford, Cornelia Beldiman, Kimberly J Payne
Journal of Investigative Medicine Mar 2016, 64 (3) 740-744; DOI: 10.1136/jim-2016-000076
- Article
- Abstract
- Introduction
- Leukemogenesis and chemoresistance are the outcome of selective processes dependent on the genetic landscape
- Leukemia models and their limitation
- CRLF2 B-ALL: A perfect leukemia storm where PDX models could be most effective
- A preclinical PDX model that provides physiological levels of human TSLP for studies of CRLF2 B-ALL
- Acknowledgments
- Footnotes
- References
- Figures & Data
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