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Relationship of 18F-FDG PET/CT metabolic, clinical and pathological characteristics of primary squamous cell carcinoma of the cervix

Weina Xu, Shupeng Yu, Jun Xin, Qiyong Guo
DOI: 10.1136/jim-2016-000166 Published 23 November 2016
Weina Xu
1Department of Nuclear Medicine, Shengjing Hospital of China Medical University, Shenyang, China
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Shupeng Yu
1Department of Nuclear Medicine, Shengjing Hospital of China Medical University, Shenyang, China
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Jun Xin
2Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, China
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Qiyong Guo
2Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, China
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Abstract

The objectives of this retrospective study were to use preoperative 18fluoro-d-glucose (18FDG) PET/CT in patients with primary cervical squamous cell carcinoma to explore the relationship between clinical, pathological and metabolic characteristics. Eighty consecutive patients with squamous cell carcinoma of cervix received 18FDG PET/CT scan before treatment. Metabolic tumor volume (MTV), total lesion glycolysis (TLG) and the peak standardized uptake value (SUVpeak) of the cervical tumors were calculated by an iterative adaptive algorithm. The association of these metabolic markers with serum squamous cell carcinoma antigen (SCC-ag), International Federation of Gynecology and Obstetrics (FIGO) stage, maximum tumor size and depth of cervical stromal invasion of the tumor was determined by the multivariate analysis. MTV and TLG were significantly higher in subjects with serum SCC-ag levels ≥3.95, with FIGO stage 1b2 and with a maximum tumor size of ≥4 cm (p≤0.009). Higher SUVpeak levels were associated with a maximum tumor size of ≥4 cm and with a cervical stromal invasion depth of ≥1/2 (p≤0.003). Multivariate analysis indicated that MTV was independently associated with FIGO stage Ib2 (p=0.041) and depth of cervical stromal invasion (p=0.020). TLG and SUVpeak were independently associated with maximum tumor size (p≤0.004) and depth of cervical stromal invasion (p≤0.013). Significant linear correlation was found between SUVpeak and tumor size; the Pearson correlation coefficient was 0.34 (p=0.002). Metabolic parameters such as MTV, TLG and SUVpeak are able to predict clinical and pathological status in preoperative cervical cancer.

Footnotes

  • Contributors WX undertook the statistical analysis, wrote the first draft of the manuscript. SY performed research/study. JX managed the literature searches and analyses. QG designed the study and wrote the protocol.

  • Competing interests None declared.

  • Ethics approval The study was performed in accordance with the Declaration of Helsinki and the protocol was approved by the Institutional Review Board of Shengjing Hospital.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Vol 64 Issue 8 Table of Contents
Journal of Investigative Medicine: 64 (8)
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Relationship of 18F-FDG PET/CT metabolic, clinical and pathological characteristics of primary squamous cell carcinoma of the cervix
Weina Xu, Shupeng Yu, Jun Xin, Qiyong Guo
Journal of Investigative Medicine Dec 2016, 64 (8) 1246-1251; DOI: 10.1136/jim-2016-000166

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Relationship of 18F-FDG PET/CT metabolic, clinical and pathological characteristics of primary squamous cell carcinoma of the cervix
Weina Xu, Shupeng Yu, Jun Xin, Qiyong Guo
Journal of Investigative Medicine Dec 2016, 64 (8) 1246-1251; DOI: 10.1136/jim-2016-000166
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Relationship of 18F-FDG PET/CT metabolic, clinical and pathological characteristics of primary squamous cell carcinoma of the cervix
Weina Xu, Shupeng Yu, Jun Xin, Qiyong Guo
Journal of Investigative Medicine Dec 2016, 64 (8) 1246-1251; DOI: 10.1136/jim-2016-000166
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