Figure 6 Cyclo-oxygenase-2 inhibition with celcecoxib and rofecoxib and expression of genes related to atherosclerosis. Gene expression analysis performed with RT2 Profiler PCR Array in THP-1 macrophages exposed to celcoxib and rofecoxib (10 µM). This array reflects changes in gene expression of proteins involved in lipid transport and metabolism (A) with corresponding regulation of transcription (B), blood coagulation (C), inflammatory response (D), and cell-to-cell adhesion (E). All results are means for three independent experiments. *p<0.05; **p<0.01 versus solvent control. (A) ABCA1, ATP-binding cassette transporter A1; APOA1, apolipoprotein A–I; APOB, apolipoprotein B; APOE, apolipoprotein E; LDLR, low-density lipoprotein receptor; SRA1, macrophage scavenger receptor A 1; LPL, lipoprotein lipase; LPA, lipoprotein (a); (B) LXR α, liver X receptor α; RXRα, retinoid X receptor α; PPARα, peroxisome proliferator-activated receptor α; PPARδ, peroxisome proliferator-activated receptor δ; PPARγ, peroxisome proliferator-activated receptor γ; (C) PDGFA, platelet-derived growth factor α; PDGFB, platelet-derived growth factor β; ELN, elastin; ENG, endoglin; FN, fibronectin; VWF, Von Willebrand factor; COL3A1, collagen α-1(III) chain; ACE, angiotensin I-converting enzyme; SERPINE1, serpin peptidase inhibitor, clade E; ITGA2, integrin α 2; (D) CCL5 (RANTES), chemokine (C–C motif) ligand 5; MCP1, monocyte chemotactic protein-1; GM-CSF, colony stimulating factor 2; ITGB2, integrin β 2; IL1α, interleukin 1 α; NFKβ, nuclear factor κ-light-chain-enhancer of activated B cells; TNF α, tumor necrosis factor α; TNFAIP3, tumor necrosis factor, α-induced protein 3; eNOS, endothelial nitric oxide synthase; SOD1, superoxide dismutase 1; (E) ICAM1, intercellular adhesion molecule 1; VCAM1, vascular cell adhesion molecule 1; VEGFA, vascular endothelial growth factor A; SELE, selectin E; LECAM1, leucocyte-endothelial adhesion molecule-1.