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Plasma MOTS-c levels are associated with insulin sensitivity in lean but not in obese individuals

Luis Rodrigo Cataldo, Rodrigo Fernández-Verdejo, José Luis Santos, Jose Eduardo Galgani
DOI: 10.1136/jim-2017-000681 Published 25 July 2018
Luis Rodrigo Cataldo
1 Departamento de Nutrición, Diabetes y Metabolismo, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
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Rodrigo Fernández-Verdejo
2 Carrera de Nutrición y Dietética, Departamento de Ciencias de la Salud, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
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José Luis Santos
1 Departamento de Nutrición, Diabetes y Metabolismo, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
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Jose Eduardo Galgani
1 Departamento de Nutrición, Diabetes y Metabolismo, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
2 Carrera de Nutrición y Dietética, Departamento de Ciencias de la Salud, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
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Abstract

Mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) is a mitochondrial-derived peptide that attenuates weight gain and hyperinsulinemia when administered to high fat-fed mice. MOTS-c is therefore a potential regulator of metabolic homeostasis under conditions of high-energy supply. However, the effect of insulin resistance and obesity on plasma MOTS-c concentration in humans is unknown. To gain insight into MOTS-c regulation, we measured plasma MOTS-c concentration and analyzed its relationship with insulin sensitivity surrogates, in lean and obese humans (n=10 per group). Obese individuals had impaired insulin sensitivity as indicated by low Matsuda and high Homeostatic Model Assessment (HOMA) indexes. Although plasma MOTS-c concentration was similar in lean and obese individuals (0.48±0.16 and 0.52±0.15 ng/mL; p=0.60), it was correlated with HOMA (r=0.53; p<0.05) and Matsuda index (r=−0.46; p<0.05). Notably, when the groups were analyzed separately, the associations remained only in lean individuals. We conclude that plasma MOTS-c concentration is unaltered in human obesity. However, MOTS-c associates positively with insulin resistance mostly in lean individuals, indicating that plasma MOTS-c concentration depends on the metabolic status in this population. Such dependence seems altered when obesity settles. The implications of plasma MOTS-c for human metabolic homeostasis deserve future examination.

Footnotes

  • LRC and RF-V contributed equally.

  • Contributors JEG, LRC and JLS conceived the study. All authors participated in data analysis and interpretation. JEG, LRC and RF-V wrote the manuscript, which was approved by all the co-authors.

  • Funding Fondo Nacional de Desarrollo Científico y Tecnológico (Fondecyt; #1130217, #1170117 and #1150416) funded the study.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval The Ethical Board at Pontificia Universidad Católica de Chile approved the protocol (Reference number: 12-201, 2012).

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Vol 66 Issue 6 Table of Contents
Journal of Investigative Medicine: 66 (6)
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Plasma MOTS-c levels are associated with insulin sensitivity in lean but not in obese individuals
Luis Rodrigo Cataldo, Rodrigo Fernández-Verdejo, José Luis Santos, Jose Eduardo Galgani
Journal of Investigative Medicine Aug 2018, 66 (6) 1019-1022; DOI: 10.1136/jim-2017-000681

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Plasma MOTS-c levels are associated with insulin sensitivity in lean but not in obese individuals
Luis Rodrigo Cataldo, Rodrigo Fernández-Verdejo, José Luis Santos, Jose Eduardo Galgani
Journal of Investigative Medicine Aug 2018, 66 (6) 1019-1022; DOI: 10.1136/jim-2017-000681
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Plasma MOTS-c levels are associated with insulin sensitivity in lean but not in obese individuals
Luis Rodrigo Cataldo, Rodrigo Fernández-Verdejo, José Luis Santos, Jose Eduardo Galgani
Journal of Investigative Medicine Aug 2018, 66 (6) 1019-1022; DOI: 10.1136/jim-2017-000681
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