CaD trial intervention | | | | | 0.45 | | | | |
Placebo | 17,172 | 1804 | 1.56 | 1.00 (ref) | | N/A | | N/A | |
Active | 17,236 | 1777 | 1.52 | 0.98 (0.91 to 1.04) | | | | | |
Dietary vitamin D, IU/day* | | | | 0.18 | | 0.16 | | 0.38 |
<200 | 99,362 | 10,292 | 1.39 | 1.00 (ref) | | 1.00 (ref) | | 1.00 (ref) | |
200–<400 | 36,681 | 3776 | 1.38 | 0.99 (0.96 to 1.03) | | 1.00 (0.97 to 1.04) | | 0.99 (0.96 to 1.03) | |
400–<600 | 5921 | 631 | 1.43 | 1.03 (0.95 to 1.11) | | 1.04 (0.96 to 1.13) | | 1.03 (0.95 to 1.11) | |
600–<800 | 978 | 118 | 1.65 | 1.21 (1.01 to 1.45) | | 1.16 (0.97 to 1.39) | | 1.15 (0.96 to 1.38) | |
≥800 | 417 | 48 | 1.59 | 1.17 (0.88 to 1.55) | | 1.11 (0.84 to 1.48) | | 1.10 (0.83 to 1.46) | |
Continuous: 200 IU increase | | | | 1.01 (0.99 to 1.04) | 0.29 | 1.02 (0.99 to 1.05) | 0.18 | 1.01 (0.98 to 1.04) | 0.49 |
Vitamin D supplements, IU/day* | | | 0.77 | | 0.45 | | 0.29 |
<200 | 81,504 | 8623 | 1.41 | 1.00 (ref) | | 1.00 (ref) | | 1.00 (ref) | |
200–<400 | 7214 | 721 | 1.35 | 0.98 (0.91 to 1.06) | | 1.01 (0.93 to 1.09) | | 1.01 (0.94 to 1.09) | |
400–<600 | 46,053 | 4660 | 1.37 | 1.00 (0.96 to 1.03) | | 1.00 (0.96 to 1.04) | | 1.00 (0.97 to 1.04) | |
600–<800 | 4843 | 457 | 1.31 | 0.98 (0.89 to 1.08) | | 1.00 (0.91 to 1.10) | | 1.01 (0.92 to 1.11) | |
≥800 | 3775 | 404 | 1.47 | 1.07 (0.97 to 1.19) | | 1.10 (0.99 to 1.21) | | 1.11 (1.01 to 1.23) | |
Continuous: 200 IU increase | | | | 1.00 (0.99 to 1.01) | >0.99 | 1.00 (0.99 to 1.02) | 0.59 | 1.01 (0.99 to 1.02) | 0.39 |
Total vitamin D, IU/day* | | | | | 0.69 | | 0.34 | | 0.33 |
<200 | 53,749 | 5691 | 1.41 | 1.00 (ref) | | 1.00 (ref) | | 1.00 (ref) | |
200–<400 | 26,569 | 2775 | 1.39 | 0.99 (0.95 to 1.04) | | 1.01 (0.97 to 1.06) | | 1.01 (0.96 to 1.05) | |
400–<600 | 35,359 | 3584 | 1.36 | 0.99 (0.95 to 1.03) | | 1.00 (0.96 to 1.04) | | 1.00 (0.96 to 1.04) | |
600–<800 | 18,587 | 1885 | 1.38 | 1.01 (0.96 to 1.06) | | 1.02 (0.97 to 1.08) | | 1.02 (0.97 to 1.08) | |
≥800 | 9125 | 930 | 1.40 | 1.03 (0.96 to 1.10) | | 1.04 (0.97 to 1.11) | | 1.04 (0.97 to 1.11) | |
Continuous: 200 IU increase | | | | 1.00 (0.99 to 1.01) | 0.62 | 1.01 (0.99 to 1.02) | 0.29 | 1.01 (0.99 to 1.02) | 0.29 |
Serum 25(OH), ng/mL, weighted† | | | | | 0.14 | | 0.37 | | 0.41 |
<30 | 9904 | 13,714 | 1.46 | 1.00 (ref) | | 1.00 (ref) | | 1.00 (ref) | |
≥30 | 948 | 1028 | 1.19 | 0.81 (0.61 to 1.08) | | 0.88 (0.66 to 1.17) | | 0.89 (0.67 to 1.18) | |
Continuous: 5 ng/mL increase | | | | 0.96 (0.91 to 1.01) | 0.11 | 0.98 (0.93 to 1.04) | 0.56 | 0.99 (0.94 to 1.04) | 0.60 |
Serum 25(OH), ng/mL, weighted† | | | | | 0.02 | | 0.15 | | 0.16 |
<20 | 6684 | 9461 | 1.56 | 1.00 (ref) | | 1.00 (ref) | | 1.00 (ref) | |
20–50 | 4141 | 5255 | 1.25 | 0.83 (0.70 to 0.97) | | 0.89 (0.75 to 1.05) | | 0.89 (0.75 to 1.05) | |
>50 | 28 | 26 | 1.18 | 0.74 (0.18 to 3.06) | | 0.84 (0.21 to 3.43) | | 0.82 (0.20 to 3.37) | |
Continuous: 5 ng/mL increase | | | | 0.96 (0.91 to 1.01) | 0.11 | 0.98 (0.93 to 1.04) | 0.56 | 0.99 (0.94 to 1.04) | 0.60 |