Benign asthma
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Mild atopic asthma, early onset
Young, active individuals. Normal lung function. Infrequent exacerbations. Activity and exercise-related symptoms are common.
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Early-onset, atopic asthma
Associated with atopy. Presents at an early age. Eosinophilic airway inflammation. High risk of morbidity. Increased healthcare utilization. Treatment should target atopic/eosinophilic inflammation.
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Moderate atopic asthma, early onset
Associated with atopy. Presents at an early age. Preserved lung function. Increased healthcare utilization. ≥3 controllers may be needed to control symptoms.
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Obese, non-eosinophilic asthma
Seen in obese female subjects. Late-onset presentation. Decreased atopy. Moderate airway hyper-reactivity and FEV1 reversibility. High healthcare utilization. Minimal eosinophilic airway inflammation. Symptom control with high-dose ICS + other controllers*. Weight loss highly recommended.
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Non-atopic asthma, late onset
Seen in obese women. Moderate decline in FEV1. High healthcare utilization. Minimal eosinophilic airway inflammation. Symptom control with high-dose ICS + other controllers*.
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Early-onset, symptom-predominant asthma
Minimal airway reversibility. Minimal eosinophilic inflammation. Requires multiple controller medications*. Challenging to treat. Usually severe, persistent.
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Severe atopic asthma with reversible airflow, early onset
Associated with atopy. Severe airway obstruction with FEV1 reversibility. High healthcare utilization, with ICU admission. Requires high-dose ICS + other controllers*. Associated with poor quality of life.
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Late-onset, inflammation-predominant asthma
Male predominant. Significant eosinophilic disease is present. Treatment should target eosinophilic inflammation. Challenging to treat. Usually severe, persistent.
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Severe ‘non-atopic’ asthma with fixed airflow, late onset
Infrequently associated with atopy. Severe airway obstruction. High healthcare utilization, with ICU admission. Challenging to treat, OCS + other controllers*. Associated with poor quality of life.
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