In this issue of the Journal of Investigative Medicine, Singh et al review the important addition of the glucagon-like peptide-1 receptor agonists (GLP-1 RAs) for the treatment of obesity and specifically discuss semaglutide for weight management. Despite the dire and costly outcomes of obesity, the USA and much of the world have failed for years to practice healthy eating and exercise. The 2017–2018 National Health and Nutrition Examination Survey (NHANES) estimated that 42.5% of US adults aged 20 and over have obesity and an additional 31.1% are overweight, impacting 73.6% of the adult population.1
Having excessive weight has now become the “norm” with those overweight or …
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