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Yet another amyloidosis

Robert T Means
DOI: 10.1136/jim-2021-002221 Published 25 January 2022
Robert T Means
Office of the Dean, East Tennessee State University, Johnson City, Tennessee, USA
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Systemic amyloidosis is a syndrome of protean manifestations and many pathophysiologies, united by the histopathologic demonstration of extracellular deposition of Congo red-positive fibrillar material that shows apple green birefringence under polarized light microscopy.1 Its clinical features vary depending on the site of amyloid deposition and the particular protein of which amyloid is comprised. Symptomatic deposition of amyloid may involve the heart, the liver, the kidneys, the stomach and intestines; the central, peripheral, or autonomic nervous systems; the lungs or upper airway; or the skin.1 Familial Mediterranean fever is an autosomal recessive disorder of amyloid deposition.2

Since it can present in so many …

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Vol 70 Issue 2 Table of Contents
Journal of Investigative Medicine: 70 (2)
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Yet another amyloidosis
Robert T Means
Journal of Investigative Medicine Feb 2022, 70 (2) 347; DOI: 10.1136/jim-2021-002221

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Yet another amyloidosis
Robert T Means
Journal of Investigative Medicine Feb 2022, 70 (2) 347; DOI: 10.1136/jim-2021-002221
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Yet another amyloidosis
Robert T Means
Journal of Investigative Medicine Feb 2022, 70 (2) 347; DOI: 10.1136/jim-2021-002221
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