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Predictive role of ultrasound remission for progressive ultrasonography-detected structural damage in patients with rheumatoid arthritis

Feifei Liu, Wenxue Li, Jiaan Zhu, Fang Liu, Wenting Fan, Zheng Chen
DOI: 10.1136/jim-2021-001885 Published 25 January 2022
Feifei Liu
Department of Ultrasound, Peking University People's Hospital, Beijing, China
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Wenxue Li
Department of Ultrasound, Peking University People's Hospital, Beijing, China
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  • ORCID record for Wenxue Li
Jiaan Zhu
Department of Ultrasound, Peking University People's Hospital, Beijing, China
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Fang Liu
Department of Ultrasound, Peking University People's Hospital, Beijing, China
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Wenting Fan
Department of Ultrasound, Peking University People's Hospital, Beijing, China
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Zheng Chen
Department of Ultrasound, Peking University People's Hospital, Beijing, China
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  • Table 1

    Ultrasound scores of patients with rheumatoid arthritis at different time points

    Ultrasonographic appearancesBaseline3 months6 months12 months
    Synovial hypertrophy12.66±9.5799.33±8.1078.84±7.2678.34±7.618
    Power Doppler signal4.00 (1.00–8.00)2.00 (0.00–5.00)2.00 (0.00–5.00)2.00 (0.00–6.00)
    Bone erosions1.00 (0.00–5.00)1.00 (0.00–5.00)2.00 (0.00–5.50)2.00 (0.00–6.00)
  • Table 2

    Interobserver agreement

    Ultrasonographic factorsKappaICCOverall agreement
    Synovial hypertrophy0.780.9188.9
    Power Doppler signal0.750.8287.4
    Bone erosions0.670.8679.8
    • ICC, intraclass correlation coefficient.

  • Table 3

    Univariate and multivariate analyses of baseline ultrasonographic factors for predicting ultrasound-detected structural damage

    Ultrasonographic factors at baselineUnivariateMultivariate
    OR (95% CI)P valueOR (95% CI)P value
    Synovial hypertrophy0.931 (0.875 to 0.991)0.0240.910 (0.822 to 1.008)0.071
    Power Doppler signal0.937 (0.862 to 1.019)0.1281.040 (0.910 to 1.188)0.566
    Bone erosions0.960 (0.852 to 1.081)0.502
  • Table 4

    Performance of clinical and ultrasound remission in identifying patients with non-progressive ultrasonography-detected structural damage

    Prevalence of non-progressive ultrasonography-detected structural damageP valueOR (95% CI)SensitivitySpecificityPPVNPV
    Patients in remission
    n/N (%)
    Patients not in remission
    n/N (%)
    Ultrasound remission at 3 months17/19 (89.47)20/42 (47.62)0.0069.350 (1.916 to 45.638)45.9591.6789.4752.38
    Ultrasound remission at 6 months19/22 (86.36)18/39 (46.15)0.0047.389 (1.876 to 29.100)51.3587.5086.3653.85
    Clinical remission at 3 months18/23 (78.26)19/38 (50.00)0.0293.600 (1.109 to 11.684)48.6579.1778.2650.00
    Clinical remission at 6 months15/20 (75.00)23/41 (56.10)0.1532.348 (0.718 to 7.681)39.4778.2675.0043.90
    • NPV, negative predictive value; PPV, positive predictive value.

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    [jim-2021-001885supp001.pdf]

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    [jim-2021-001885supp002.pdf]

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    This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

    • Data supplement 1
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Journal of Investigative Medicine: 70 (2)
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Predictive role of ultrasound remission for progressive ultrasonography-detected structural damage in patients with rheumatoid arthritis
Feifei Liu, Wenxue Li, Jiaan Zhu, Fang Liu, Wenting Fan, Zheng Chen
Journal of Investigative Medicine Feb 2022, 70 (2) 391-395; DOI: 10.1136/jim-2021-001885

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Predictive role of ultrasound remission for progressive ultrasonography-detected structural damage in patients with rheumatoid arthritis
Feifei Liu, Wenxue Li, Jiaan Zhu, Fang Liu, Wenting Fan, Zheng Chen
Journal of Investigative Medicine Feb 2022, 70 (2) 391-395; DOI: 10.1136/jim-2021-001885
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Predictive role of ultrasound remission for progressive ultrasonography-detected structural damage in patients with rheumatoid arthritis
Feifei Liu, Wenxue Li, Jiaan Zhu, Fang Liu, Wenting Fan, Zheng Chen
Journal of Investigative Medicine Feb 2022, 70 (2) 391-395; DOI: 10.1136/jim-2021-001885
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