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Opium may affect coronary artery disease by inducing inflammation but not through the expression of CD9, CD36, and CD68

Mohammad Amin Momeni-Moghaddam, Gholamreza Asadikaram, Mohammad Masoumi, Erfan Sadeghi, Hamed Akbari, Moslem Abolhassani, Alireza Farsinejad, Morteza Khaleghi, Mohammad Hadi Nematollahi, Shahriar Dabiri, Mohammad Kazemi Arababadi
DOI: 10.1136/jim-2021-001935 Published 1 December 2022
Mohammad Amin Momeni-Moghaddam
1 Nutrition and Biochemistry, Gonabad University of Medical Sciences, Gonabad, Iran (the Islamic Republic of)
2 Department of Clinical Biochemistry, Afzalipur Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran (the Islamic Republic of)
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Gholamreza Asadikaram
2 Department of Clinical Biochemistry, Afzalipur Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran (the Islamic Republic of)
3 Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran (the Islamic Republic of)
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Mohammad Masoumi
4 Cardiovascular Research Center, Institute of Basic and Clinical ‎Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
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Erfan Sadeghi
5 Fasa University of Medical Sciences, Fasa, Iran (the Islamic Republic of)
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Hamed Akbari
6 Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
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Moslem Abolhassani
7 Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences,Kerman University of Medical Sciences, Kerman, Iran
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Alireza Farsinejad
8 Pathology and Stem Cell Research Center, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
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Morteza Khaleghi
8 Pathology and Stem Cell Research Center, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
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Mohammad Hadi Nematollahi
9 Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran
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Shahriar Dabiri
8 Pathology and Stem Cell Research Center, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
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Mohammad Kazemi Arababadi
10 Rafsanjan University of Medical Sciences, Rafsanjan, Iran (the Islamic Republic of)
11 Department of Laboratory Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran (the Islamic Republic of)
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Abstract

The molecular mechanisms of opium with regard to coronary artery disease (CAD) have not yet been determined. The aim of the present study was to evaluate the effect of opium on the expression of scavenger receptors including CD36, CD68, and CD9 tetraspanin in monocytes and the plasma levels of tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), malondialdehyde (MDA), and nitric oxide metabolites (NOx) in patients with CAD with and without opium addiction. This case–control study was conducted in three groups: (1) opium-addicted patients with CAD (CAD+OA, n=30); (2) patients with CAD with no opium addiction (CAD, n=30); and (3) individuals without CAD and opium addiction as the control group (Ctrl, n=17). Protein and messenger RNA (mRNA) levels of CD9, CD36, and CD68 were evaluated by flow cytometry and reverse transcription-quantitative PCR methods, respectively. Consumption of atorvastatin, aspirin, and glyceryl trinitrate was found to be higher in the CAD groups compared with the control group. The plasma level of TNF-α was significantly higher in the CAD+OA group than in the CAD and Ctrl groups (p=0.001 and p=0.005, respectively). MDA levels significantly increased in the CAD and CAD+OA groups in comparison with the Ctrl group (p=0.010 and p=0.002, respectively). No significant differences were found in CD9, CD36, CD68, IFN-γ, and NOx between the three groups. The findings demonstrated that opium did not have a significant effect on the expression of CD36, CD68, and CD9 at the gene and protein levels, but it might be involved in the development of CAD by inducing inflammation through other mechanisms.

Footnotes

  • Contributors MA-MM, GA, and MK set up the study design and interpretation of the data. MA-MM, GA, ES, and HA performed statistical analyses, interpretation of the data, and original draft preparation. GA, HA, and MA-MM revised manuscript critically and provide of continuous guidance throughout the study. MA-MM, MA, MHN, AF, MK, and SD collection of data and performing the experiments. All authors read and approved the final manuscript. GA is responsible for the overall content as the guarantor.

  • Funding This work was supported by a grant from the Kerman University of Medical Sciences (IR/KMU/95/212).

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.

Data availability statement

Data are available upon reasonable request.

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Vol 70 Issue 8 Table of Contents
Journal of Investigative Medicine: 70 (8)
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Opium may affect coronary artery disease by inducing inflammation but not through the expression of CD9, CD36, and CD68
Mohammad Amin Momeni-Moghaddam, Gholamreza Asadikaram, Mohammad Masoumi, Erfan Sadeghi, Hamed Akbari, Moslem Abolhassani, Alireza Farsinejad, Morteza Khaleghi, Mohammad Hadi Nematollahi, Shahriar Dabiri, Mohammad Kazemi Arababadi
Journal of Investigative Medicine Dec 2022, 70 (8) 1728-1735; DOI: 10.1136/jim-2021-001935

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Opium may affect coronary artery disease by inducing inflammation but not through the expression of CD9, CD36, and CD68
Mohammad Amin Momeni-Moghaddam, Gholamreza Asadikaram, Mohammad Masoumi, Erfan Sadeghi, Hamed Akbari, Moslem Abolhassani, Alireza Farsinejad, Morteza Khaleghi, Mohammad Hadi Nematollahi, Shahriar Dabiri, Mohammad Kazemi Arababadi
Journal of Investigative Medicine Dec 2022, 70 (8) 1728-1735; DOI: 10.1136/jim-2021-001935
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Opium may affect coronary artery disease by inducing inflammation but not through the expression of CD9, CD36, and CD68
Mohammad Amin Momeni-Moghaddam, Gholamreza Asadikaram, Mohammad Masoumi, Erfan Sadeghi, Hamed Akbari, Moslem Abolhassani, Alireza Farsinejad, Morteza Khaleghi, Mohammad Hadi Nematollahi, Shahriar Dabiri, Mohammad Kazemi Arababadi
Journal of Investigative Medicine Dec 2022, 70 (8) 1728-1735; DOI: 10.1136/jim-2021-001935
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