Article Figures & Data
Figures
- Figure 1
Differences in zDC values between the two subject groups. Red and blue colors indicate higher and lower zDC values, respectively, in patients with non-NP-SLE than in healthy controls. Results are displayed at p<0.05 corrected by AlphaSim (voxel-level p<0.01, cluster-level p<0.05, cluster size >27 voxels). DC, degree centrality; L, left; non-NP-SLE, non-neuropsychiatric systemic lupus erythematosus; R, right.
- Figure 2
Correlations between zDC values and clinical and neuropsychological data. DC, degree centrality; MMSE, Mini-Mental State Examination; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index.
- Figure 3
ROC curve analysis of the zDC values of altered brain regions. AUC, area under the curve; DC, degree centrality; LFMO, orbital part of the left superior frontal gyrus; LPG, left postcentral gyrus; ROC, receiver operating characteristics; RPG, right postcentral gyrus.
Tables
- Table 1
Demographic and clinical characteristics of patients with non-NP-SLE and HC
Items Non-NP-SLE (n=28) HC (n=27) z/X2 value P value Age (years) 46.2±10.0 45.1±4.7 −1.467 0.142* Disease duration (years) 8.1±6.1 – – Education (years) 9.7±3.4 12.3±3.8 −2.445 0.014* MMSE 26.89±2.77 29.59±0.57 −4.942 <0.001* HADS-A 7.39±5.01 1.74±1.77 −4.753 <0.001* HADS-D 5.75±4.33 1.07±1.07 −4.890 <0.001* FSMC-C 29.71±9.03 – FSMC-M 30.71±9.51 – C3 (g/L) 0.89±0.23 C4 (g/L) 0.16±0.71 IgA 2.24±1.62 IgM 0.88±0.33 SLEDAI 3.61±3.21 P<0.05 was considered to indicate significant difference.
*Significant difference between groups.
FSMC-C, Fatigue Scale for Motor and Cognitive Functions-subscale for cognitive fatigue; FSMC-M, Fatigue Scale for Motor and Cognitive Functions-subscale for motor fatigue; HADS-A, Hospital Anxiety and Depression Scale-anxiety subscale; HADS-D, Hospital Anxiety and Depression Scale-depression subscale; HC, healthy control; MMSE, Mini-Mental State Examination; non-NP-SLE, non-neuropsychiatric systemic lupus erythematosus ; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index.
- Table 2
Brain regions with different zDC values between two groups
Region Cluster size (voxels) MNI coordinates (mm) t value x y z Non-NP-SLE > HC RPG 32 33 −48 69 4.34 LPG 29 −24 −30 75 3.96 Non-NP-SLE < HC LFMO 28 −6 51 −6 −4.17 Results are displayed at p<0.05 corrected by AlphaSim (voxel-level p<0.01, cluster-level p<0.05, cluster size >27 voxels).
DC, degree centrality; HC, healthy control; LFMO, orbital part of the left superior frontal gyrus; LPG, left postcentral gyrus; MNI, Montreal Neurological Institute; non-NP-SLE, non-neuropsychiatric systemic lupus erythematosus; RPG, right postcentral gyrus.
- Table 3
ROC analysis of the zDC values of altered brain regions
Brain regions AUC P value 95% CI Sensitivity Specificity Cut-off RPG 0.865 0.000 0.772 to 0.958 0.815 0.786 0.472 LPG 0.812 0.000 0.692 to 0.932 0.926 0.714 0.631 LFMO 0.139 0.000 0.036 to 0.242 0.964 0.037 −0.597 AUC, area under the curve; DC, degree centrality; LFMO, the orbital part of the left superior frontal gyrus; LPG, left postcentral gyrus; ROC, receiver operating characteristics; RPG, right postcentral gyrus.
