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Altered degree centrality in patients with non-neuropsychiatric systemic lupus erythematosus: a resting-state fMRI study

Xiaolou Li, Peng Zhang, Wensu Zhou, Yuan Li, Zhongru Sun, Jinhua Chen, Jianguo Xia, Hongmei Zou
DOI: 10.1136/jim-2021-001941 Published 19 January 2022
Xiaolou Li
1Graduate School Of Dalian Medical University, Dalian, Liaoning, China
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Peng Zhang
1Graduate School Of Dalian Medical University, Dalian, Liaoning, China
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Wensu Zhou
1Graduate School Of Dalian Medical University, Dalian, Liaoning, China
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Yuan Li
2Department of Radiology, Jiangsu Taizhou People's Hospital, Taizhou, Jiangsu, China
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Zhongru Sun
2Department of Radiology, Jiangsu Taizhou People's Hospital, Taizhou, Jiangsu, China
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Jinhua Chen
2Department of Radiology, Jiangsu Taizhou People's Hospital, Taizhou, Jiangsu, China
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Jianguo Xia
2Department of Radiology, Jiangsu Taizhou People's Hospital, Taizhou, Jiangsu, China
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Hongmei Zou
3Department of Rheumatology and Immunology, Jiangsu Taizhou People's Hospital, Taizhou, Jiangsu, China
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Abstract

This study used a voxel-wise degree centrality (DC) method to evaluate differences in brain activity between patients with non-neuropsychiatric systemic lupus erythematosus (non-NP-SLE) and healthy controls (HCs) and to assess the relationship of DC values with clinical and neuropsychological data. Thirty-two female patients with non-NP-SLE and 28 well-matched HCs were recruited and underwent resting-state functional MRI. Differences in spontaneous brain activity between the two groups were evaluated using a DC method. Correlations between the altered DC values of specific brain regions and clinical and neuropsychological data were explored using Spearman correlation analysis. Receiver operating characteristics curve analysis was applied to differences in DC values in specific brain regions to determine their value in distinguishing patients with non-NP-SLE from HCs. Compared with HCs, DC values in patients with non-NP-SLE were significantly lower in the bilateral postcentral gyrus and the orbital part of the left superior frontal gyrus (LFMO). DC values in some specific brain regions such as the bilateral postcentral gyrus and the LFMO correlated with Mini-Mental State Examination scores in both subject groups. In patients with non-NP-SLE, DC values of the right postcentral gyrus were positively correlated with IgA levels, and DC values of the LFMO were positively correlated with Systemic Lupus Erythematosus Disease Activity Index 2000 scores, as well as IgA levels. Receiver operating characteristics curve analysis revealed that the DC values of specific brain regions can be used to differentiate patients with non-NP-SLE from HCs.

Footnotes

  • Contributors JX acts as guarantor. JX, JC, and HZ designed the study and revised the manuscript. XL, PZ, WZ, YL, ZS, and JC performed the experiments and collected the data. PZ, WZ, YL, and ZS analyzed the data. XL drafted the manuscript. All authors reviewed and edited the manuscript and approved the final version.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Data availability statement

Data are available upon reasonable request.

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Vol 70 Issue 4 Table of Contents
Journal of Investigative Medicine: 70 (4)
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Altered degree centrality in patients with non-neuropsychiatric systemic lupus erythematosus: a resting-state fMRI study
Xiaolou Li, Peng Zhang, Wensu Zhou, Yuan Li, Zhongru Sun, Jinhua Chen, Jianguo Xia, Hongmei Zou
Journal of Investigative Medicine Jan 2022, jim-2021-001941; DOI: 10.1136/jim-2021-001941

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Altered degree centrality in patients with non-neuropsychiatric systemic lupus erythematosus: a resting-state fMRI study
Xiaolou Li, Peng Zhang, Wensu Zhou, Yuan Li, Zhongru Sun, Jinhua Chen, Jianguo Xia, Hongmei Zou
Journal of Investigative Medicine Jan 2022, jim-2021-001941; DOI: 10.1136/jim-2021-001941
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Altered degree centrality in patients with non-neuropsychiatric systemic lupus erythematosus: a resting-state fMRI study
Xiaolou Li, Peng Zhang, Wensu Zhou, Yuan Li, Zhongru Sun, Jinhua Chen, Jianguo Xia, Hongmei Zou
Journal of Investigative Medicine Jan 2022, jim-2021-001941; DOI: 10.1136/jim-2021-001941
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