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Evaluation of dynamic thiol-disulfide homeostasis and ischemia-modified albumin levels in patients with chronic lymphocytic leukemia

Huseyin Erdal, Rafiye Ciftciler, Sibel Cigdem Tuncer, Oguzhan Özcan
DOI: 10.1136/jim-2022-002568 Published 29 August 2022
Huseyin Erdal
1Medical Genetics, Aksaray University, Aksaray, Turkey
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Rafiye Ciftciler
2Hematology, Aksaray University, Aksaray, Turkey
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Sibel Cigdem Tuncer
3Biochemistry, Aksaray University, Aksaray, Turkey
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Oguzhan Özcan
4Biochemistry, Hatay Mustafa Kemal University, Hatay, Turkey
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Abstract

This is the first study to evaluate both the dynamic thiol-disulfide homeostasis and ischemia-modified albumin (IMA) levels in patients with chronic lymphocytic leukemia (CLL). Twenty-nine patients with CLL and 20 controls were included in the study. The dynamic thiol-disulfide balance was determined by the newly developed colorimetric method by Erel. IMA levels were determined by the cobalt binding test. We found that total antioxidant status levels were lower while total oxidant status (TOS) and oxidative stress index (OSI) levels were significantly higher in patients with CLL than controls. Moreover, native and total thiol levels were found to be statistically significant between the study and control groups (p<0.001), whereas no statistically significant difference was noted for IMA levels (p=0.365). A negative correlation was observed between native and total thiol levels, leukocyte, lymphocyte, and TOS. Total bilirubin showed positive correlation with direct bilirubin and alkaline phosphatase. In addition, IMA levels showed a positive correlation with OSI. This study highlights measurement of native and total thiol and IMA levels in patients with CLL for the first time. Dynamic thiol-disulfide homeostasis may contribute in the pathophysiological mechanism, and follow-up to disease in patients with CLL.

Footnotes

  • Contributors Conception and design of the research: HE. Acquisition of data: HE, RC, OÖ, SCT. Analysis and interpretation of data: HE, RC, OÖ. Statistical analysis: HE. Drafting the manuscript: HE. Revision of manuscript for important intellectual content: HE, RC, OÖ, SCT. Guarantor: HE.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.

Data availability statement

No data are available.

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Vol 70 Issue 8 Table of Contents
Journal of Investigative Medicine: 70 (8)
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Evaluation of dynamic thiol-disulfide homeostasis and ischemia-modified albumin levels in patients with chronic lymphocytic leukemia
Huseyin Erdal, Rafiye Ciftciler, Sibel Cigdem Tuncer, Oguzhan Özcan
Journal of Investigative Medicine Aug 2022, jim-2022-002568; DOI: 10.1136/jim-2022-002568

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Evaluation of dynamic thiol-disulfide homeostasis and ischemia-modified albumin levels in patients with chronic lymphocytic leukemia
Huseyin Erdal, Rafiye Ciftciler, Sibel Cigdem Tuncer, Oguzhan Özcan
Journal of Investigative Medicine Aug 2022, jim-2022-002568; DOI: 10.1136/jim-2022-002568
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Evaluation of dynamic thiol-disulfide homeostasis and ischemia-modified albumin levels in patients with chronic lymphocytic leukemia
Huseyin Erdal, Rafiye Ciftciler, Sibel Cigdem Tuncer, Oguzhan Özcan
Journal of Investigative Medicine Aug 2022, jim-2022-002568; DOI: 10.1136/jim-2022-002568
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