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Open Access

Higher serum triglyceride can predict recurrent coronary revascularization events in patients undergoing percutaneous coronary intervention with baseline LDL-C <55 mg/dL

Xiaojuan Fan, Xiaoke Wang, Jianqing She, Xiaoqian Niu, Yongbai Luo, Wen Xi, Tao Zheng, Yue Wu
DOI: 10.1136/jim-2022-002401 Published 2 September 2022
Xiaojuan Fan
1Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
2Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, Shaanxi, China
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  • ORCID record for Xiaojuan Fan
Xiaoke Wang
1Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
2Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, Shaanxi, China
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Jianqing She
1Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
2Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, Shaanxi, China
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Xiaoqian Niu
1Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
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Yongbai Luo
1Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
2Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, Shaanxi, China
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Wen Xi
3Department of Clinical Laboratory, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
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Tao Zheng
1Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
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Yue Wu
1Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
2Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, Shaanxi, China
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    Figure 1

    Study flowchart. LDL-C, low-density lipoprotein cholesterol; PCI, percutaneous coronary intervention.

  • Figure 2
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    Figure 2

    Kaplan-Meier analysis demonstrated that a higher triglyceride (TG) level (≥1.17 mmol/L) resulted in a higher risk of recurrent revascularization events than a lower TG level (<1.17 mmol/L) (p=0.021 by log-rank test).

Tables

  • Figures
  • Table 1

    Comparison of clinical, laboratory, and angiographic characteristics and clinical outcomes between two groups

    The whole
    (n=388)
    Non-revascularization group
    (n=356)
    Revascularization group
    (n=32)
    P value
    Male, n (%)307 (79.1)280 (78.7)27 (84.4)0.431
    Age, years63±1063±1064±100.895
    Presentation, n (%)0.405
     UA287 (74.0)261 (73.3)26 (81.3)
     STEMI63 (16.2)58 (16.3)5 (15.6)
     NSTEMI29 (7.5)28 (7.9)1 (3.1)
     Ischemic cardiomyopathy9 (2.3)9 (2.5)0 (0)
    History of disease, n (%)
     AF24 (6.2)23 (6.5)1 (3.1)0.708
     OMI51 (13.1)47 (13.2)4 (12.5)1
     Previous PCI26 (6.7)24 (6.7)2 (6.3)0.998
     HP242 (62.4)221 (62.1)21 (65.6)0.547
     DM145 (37.4)132 (37.1)13 (40.6)0.693
     Previous stroke19 (4.9)19 (5.3)0 (0)0.387
    Laboratory test
     ALT, U/L25 (16–38)25 (16–38)29 (19–47)0.223
     ALB, g/L39.2 (36.6–41.8)39.2 (36.7–41.7)39.1 (34.9–42.3)0.739
     CRE, mmol/L70 (60–83)69 (59–82)77 (67–86)0.030
     HbA1c, mmol/L5.9 (5.4–6.8)5.8 (5.4–6.8)6.2 (5.4–7.3)0.261
     HB, g/L132 (122–140)132 (122–140)131 (120–143)0.948
     PLT, 109 /L170 (137–210)170 (136–210)175 (146–219)0.409
     TC, mmol/L2.57 (2.37–2.76)2.56 (2.37–2.76)2.63 (2.46–2.73)0.402
     TG, mmol/L0.99 (0.77–1.33)0.97 (0.76–1.29)1.24 (0.83–1.43)0.078
     HDL-C, mmol/L0.83 (0.72–0.95)0.83 (0.72–0.95)0.82 (0.68–0.96)0.845
     LDL-C, mmol/L1.21 (1.07–1.32)1.21 (1.07–1.32)1.21 (1.02–1.35)0.780
     Lipoprotein(a), mg/L115 (59–220)113 (58–219)145 (75–229)0.354
     LVEF, %63 (53–69)63 (53–69)63 (50–71)0.943
    Angiographic characteristics, n (%)0.030
     1-vessel58 (14.9)57 (16.0)1 (3.1)
     2-vessel109 (28.1)102 (28.7)7 (21.9)
     Multi-vessel221 (575)197 (55.3)24 (75.0)
    Follow-up, n (%)
     All-cause death38 (9.8)38 (10.7)0 (0)0.058
     AMI11 (2.8)0 (0)11 (34.4)<0.001
     Angina70 (18)49 (13.8)21 (65.6)<0.001
     Stroke5 (1.3)5 (1.4)0 (0)1
    • AF, atrial fibrillation; ALB, serum albumin; ALT, alanine aminotransferase; AMI, acute myocardial infarction; CRE, creatinine; DM, diabetes mellitus; HB, hemoglobin; HDL-C, high-density lipoprotein cholesterol; HP, hypertension; LDL-C, low-density lipoprotein cholesterol; LVEF, left ventricular ejection fraction; NSTEMI, non-ST-segment elevation myocardial infarction; OMI, old myocardial infarction; PCI, percutaneous coronary intervention; PLT, platelet; STEMI, ST-segment elevation myocardial infarction; TC, total cholesterol; TG, triglyceride; UA, unstable angina.

  • Table 2

    Univariate Cox regression for predictors of recurrent revascularization and all-cause death

    VariablesRecurrent revascularizationAll-cause death
    HR95% CIP valueHR95% CIP value
    Age0.9720.944 to 1.0010.0551.0350.996 to 1.0760.083
    Female0.5980.229 to 1.5610.2932.3741.226 to 4.5980.010
    History of AF0.3200.043 to 2.3550.2632.7001.215 to 5.9990.015
    History of OMI0.9170.315 to 2.6990.8730.8450.297 to 2.4000.751
    History of HP1.0690.512 to 2.2290.8590.8750.448 to 1.7090.697
    History of DM1.0810.516 to 2.2260.8371.2110.616 to 2.3820.579
    Previous PCI1.9380.956 to 3.9270.3660.6700.324 to 1.3860.281
    ALT0.9990.995 to 1.0020.4661.0000.999 to 1.0020.434
    CRE1.0010.990 to 1.0120.8971.0060.998 to 1.0150.136
    HbA1c0.9900.781 to 1.2550.9361.1090.912 to 1.3500.300
    HB1.0140.994 to 1.0340.2680.9800.964 to 0.9960.016
    PLT1.0010.995 to 1.0070.7711.0030.997 to 1.0080.365
    TC1.6470.497 to 5.4730.4151.6260.566 to 4.6650.366
    TG1.6911.178 to 2.4280.0040.7450.371 to 1.4950.407
    HDL-C0.6820.133 to 3.5000.6472.5210.607 to 10.4670.203
    Lipoprotein(a)1.0020.999 to 1.0040.1811.0010.998 to 1.0030.566
    LVEF0.9990.969 to 1.0310.9640.9940.966 to 1.0220.668
    Multi-vessel disease1.4110.628 to 3.1700.4040.4670.241 to 0.9010.023
    • AF, atrial fibrillation; ALT, alanine aminotransferase; CRE, creatinine; DM, diabetes mellitus; HB, hemoglobin; HDL-C, high-density lipoprotein cholesterol; HP, hypertension; LVEF, left ventricular ejection fraction; OMI, old myocardial infarction; PCI, percutaneous coronary intervention; PLT, platelet; TC, total cholesterol; TG, triglyceride.

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Journal of Investigative Medicine: 70 (8)
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Higher serum triglyceride can predict recurrent coronary revascularization events in patients undergoing percutaneous coronary intervention with baseline LDL-C <55 mg/dL
Xiaojuan Fan, Xiaoke Wang, Jianqing She, Xiaoqian Niu, Yongbai Luo, Wen Xi, Tao Zheng, Yue Wu
Journal of Investigative Medicine Sep 2022, jim-2022-002401; DOI: 10.1136/jim-2022-002401

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Higher serum triglyceride can predict recurrent coronary revascularization events in patients undergoing percutaneous coronary intervention with baseline LDL-C <55 mg/dL
Xiaojuan Fan, Xiaoke Wang, Jianqing She, Xiaoqian Niu, Yongbai Luo, Wen Xi, Tao Zheng, Yue Wu
Journal of Investigative Medicine Sep 2022, jim-2022-002401; DOI: 10.1136/jim-2022-002401
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Higher serum triglyceride can predict recurrent coronary revascularization events in patients undergoing percutaneous coronary intervention with baseline LDL-C <55 mg/dL
Xiaojuan Fan, Xiaoke Wang, Jianqing She, Xiaoqian Niu, Yongbai Luo, Wen Xi, Tao Zheng, Yue Wu
Journal of Investigative Medicine Sep 2022, jim-2022-002401; DOI: 10.1136/jim-2022-002401
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