RT Journal Article SR Electronic T1 Does aspirin use reduce the risk for cancer? JF Journal of Investigative Medicine JO J Investig Med FD BMJ Publishing Group Ltd SP 391 OP 392 DO 10.1136/jim-2016-000275 VO 65 IS 2 A1 Usman Iqbal A1 Hsuan-Chia Yang A1 Wen-Shan Jian A1 Yun Yen A1 Yu-Chuan (Jack) Li YR 2017 UL http://hw-f5-jim.highwire.org/content/65/2/391.abstract AB Recently, studies have reported that aspirin has chemopreventive properties. In this study, we used the Taiwan NHI database, which covers a population of 23 million (99.99%) Taiwanese from 2001 to 2011. This was a case–control study which identified 601,733 patients using ICD-9-CM codes who were diagnosed with cancer. Each case with 4 eligible controls was matched for age, sex, and index date and adjusted for confounding factors. The observed overall cancer risk (adjusted OR (AOR), 0.95; 95% CI 0.94 to 0.96) reduced with aspirin use, specifically, colorectal (AOR, 0.97; 95% CI 0.94 to 0.99) and digestive system (AOR, 0.96; 95% CI 0.94 to 0.98) cancers. Findings from the Asian population would contribute to the discussion on aspirin's safety profile.