RT Journal Article
SR Electronic
T1 NanoSIMS imaging: an approach for visualizing and quantifying lipids in cells and tissues
JF Journal of Investigative Medicine
JO J Investig Med
FD BMJ Publishing Group Ltd
SP 669
OP 672
DO 10.1136/jim-2016-000239
VO 65
IS 3
A1 Cuiwen He
A1 Loren G Fong
A1 Stephen G Young
A1 Haibo Jiang
YR 2017
UL http://hw-f5-jim.highwire.org/content/65/3/669.abstract
AB Over the past few decades, several approaches have been used to image lipids in cells and tissues, but most have limited spatial resolution and sensitivity. Here, we discuss a relatively new approach, nanoscale secondary ion mass spectrometry imaging, that makes it possible to visualize lipids in cells and tissues in a quantitative fashion and with high spatial resolution and high sensitivity.