RT Journal Article
SR Electronic
T1 Paradigms in chronic obstructive pulmonary disease: phenotypes, immunobiology, and therapy with a focus on vascular disease
JF Journal of Investigative Medicine
JO J Investig Med
FD BMJ Publishing Group Ltd
SP jim-2016-000358
DO 10.1136/jim-2016-000358
A1 Michael Schivo
A1 Timothy E Albertson
A1 Angela Haczku
A1 Nicholas J Kenyon
A1 Amir A Zeki
A1 Brooks T Kuhn
A1 Samuel Louie
A1 Mark V Avdalovic
YR 2017
UL http://hw-f5-jim.highwire.org/content/early/2017/03/03/jim-2016-000358.abstract
AB Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous syndrome that represents a major global health burden. COPD phenotypes have recently emerged based on large cohort studies addressing the need to better characterize the syndrome. Though comprehensive phenotyping is still at an early stage, factors such as ethnicity and radiographic, serum, and exhaled breath biomarkers have shown promise. COPD is also an immunological disease where innate and adaptive immune responses to the environment and tobacco smoke are altered. The frequent overlap between COPD and other systemic diseases, such as cardiovascular disease, has influenced COPD therapy, and treatments for both conditions may lead to improved patient outcomes. Here, we discuss current paradigms that center on improving the definition of COPD, understanding the immunological overlap between COPD and vascular inflammation, and the treatment of COPD—with a focus on comorbid cardiovascular disease.