RT Journal Article
SR Electronic
T1 <em>Pneumocystis</em> colonization in asthmatic patients not receiving oral corticosteroid therapy
JF Journal of Investigative Medicine
JO J Investig Med
FD BMJ Publishing Group Ltd
SP 800
OP 802
DO 10.1136/jim-2016-000381
VO 65
IS 4
A1 Davey, Emma L
A1 Colombo, Rhonda E
A1 Fiorentino, Charles
A1 Fahle, Gary
A1 Davey, Richard T
A1 Olivier, Kenneth N
A1 Kovacs, Joseph A
YR 2017
UL http://jim.bmj.com/content/65/4/800.abstract
AB Pneumocystis jirovecii can colonize patients with chronic obstructive pulmonary disease. To determine if colonization occurs in asthma patients, sputum samples from 10 patients with mild asthma, who were not receiving oral corticosteroids, were evaluated by a sensitive real-time PCR assay that targets a multicopy gene of P. jirovecii. 2 patients (20%) had Pneumocystis DNA detected; 1 patient had 3 positive samples over an 11-day period. Thus, Pneumocystis colonization occurs in asthma patients, and further studies are warranted to evaluate its role in airways disease.Trial registration number NCT01113034.