RT Journal Article
SR Electronic
T1 Adipose tissue inflammation in insulin resistance: review of mechanisms mediating anti-inflammatory effects of omega-3 polyunsaturated fatty acids
JF Journal of Investigative Medicine
JO J Investig Med
FD BMJ Publishing Group Ltd
SP 1021
OP 1027
DO 10.1136/jim-2017-000535
VO 65
IS 7
A1 Mandana Pahlavani
A1 Theresa Ramalho
A1 Iurii Koboziev
A1 Monique J LeMieux
A1 Shasika Jayarathne
A1 Latha Ramalingam
A1 Luciano R Filgueiras
A1 Naima Moustaid-Moussa
YR 2017
UL http://hw-f5-jim.highwire.org/content/65/7/1021.abstract
AB Obesity is an increasingly costly and widespread epidemic, effecting 1 in 10 adults worldwide. It has been causally linked with both the metabolic syndrome and insulin resistance, both of which are associated with increased chronic inflammation. The exact mechanisms through which inflammation may contribute to both MetS and IR are numerous and their details are still largely unknown. Recently, micro-RNAs (miRNAs) have emerged as potential interventional targets due to their potential preventive roles in the pathogenesis of several diseases, including MetS and obesity. The purpose of this review paper is to discuss some of the known roles of miRNAs as mediators of inflammation-associated obesity and IR and how omega-3 polyunsaturated fatty acids may be used as a nutritional intervention for these disorders.