RT Journal Article
SR Electronic
T1 Two microRNA signatures for malignancy and immune infiltration predict overall survival in advanced epithelial ovarian cancer
JF Journal of Investigative Medicine
JO J Investig Med
FD BMJ Publishing Group Ltd
SP 1068
OP 1076
DO 10.1136/jim-2017-000457
VO 65
IS 7
A1 Ilya Korsunsky
A1 Janaki Parameswaran
A1 Iuliana Shapira
A1 John Lovecchio
A1 Andrew Menzin
A1 Jill Whyte
A1 Lisa Dos Santos
A1 Sharon Liang
A1 Tawfiqul Bhuiya
A1 Mary Keogh
A1 Houman Khalili
A1 Cassandra Pond
A1 Anthony Liew
A1 Andrew Shih
A1 Peter K Gregersen
A1 Annette T Lee
YR 2017
UL http://hw-f5-jim.highwire.org/content/65/7/1068.abstract
AB MicroRNAs have been established as key regulators of tumor gene expression and as prime biomarker candidates for clinical phenotypes in epithelial ovarian cancer (EOC). We analyzed the coexpression and regulatory structure of microRNAs and their co-localized gene targets in primary tumor tissue of 20 patients with advanced EOC in order to construct a regulatory signature for clinical prognosis. We performed an integrative analysis to identify two prognostic microRNA/mRNA coexpression modules, each enriched for consistent biological functions. One module, enriched for malignancy-related functions, was found to be upregulated in malignant versus benign samples. The second module, enriched for immune-related functions, was strongly correlated with imputed intratumoral immune infiltrates of T cells, natural killer cells, cytotoxic lymphocytes, and macrophages. We validated the prognostic relevance of the immunological module microRNAs in the publicly available The Cancer Genome Atlas data set. These findings provide novel functional roles for microRNAs in the progression of advanced EOC and possible prognostic signatures for survival.