RT Journal Article
SR Electronic
T1 Advanced body composition assessment: from body mass index to body composition profiling
JF Journal of Investigative Medicine
JO J Investig Med
FD BMJ Publishing Group Ltd
SP 1
OP 9
DO 10.1136/jim-2018-000722
VO 66
IS 5
A1 Magnus Borga
A1 Janne West
A1 Jimmy D Bell
A1 Nicholas C Harvey
A1 Thobias Romu
A1 Steven B Heymsfield
A1 Olof Dahlqvist Leinhard
YR 2018
UL http://hw-f5-jim.highwire.org/content/66/5/1.10.abstract
AB This paper gives a brief overview of common non-invasive techniques for body composition analysis and a more in-depth review of a body composition assessment method based on fat-referenced quantitative MRI. Earlier published studies of this method are summarized, and a previously unpublished validation study, based on 4753 subjects from the UK Biobank imaging cohort, comparing the quantitative MRI method with dual-energy X-ray absorptiometry (DXA) is presented. For whole-body measurements of adipose tissue (AT) or fat and lean tissue (LT), DXA and quantitative MRIs show excellent agreement with linear correlation of 0.99 and 0.97, and coefficient of variation (CV) of 4.5 and 4.6 per cent for fat (computed from AT) and LT, respectively, but the agreement was found significantly lower for visceral adipose tissue, with a CV of >20 per cent. The additional ability of MRI to also measure muscle volumes, muscle AT infiltration and ectopic fat, in combination with rapid scanning protocols and efficient image analysis tools, makes quantitative MRI a powerful tool for advanced body composition assessment.