PT  - JOURNAL ARTICLE
AU  - Yuxuan Li
AU  - Lutian Yao
AU  - Siyan Liu
AU  - Jisheng Wu
AU  - Liping Xia
AU  - Hui Shen
AU  - Jing Lu
TI  - Elevated serum IL-35 levels in rheumatoid arthritis are associated with disease activity
AID  - 10.1136/jim-2018-000814
DP  - 2019 Mar 01
TA  - Journal of Investigative Medicine
PG  - 707--710
VI  - 67
IP  - 3
4099  - http://hw-f5-jim.highwire.org/content/67/3/707.short
4100  - http://hw-f5-jim.highwire.org/content/67/3/707.full
SO  - J Investig Med2019 Mar 01; 67
AB  - To investigate serum interleukin (IL)- 35 levels in patients with rheumatoid arthritis (RA) and to describe the association between serum IL-35 levels and clinical parameters: erythrocyte sedimentation rate (ESR), C reactive protein (CRP), global health on Visual Analog Scale, Disease Activity Score in 28 joints based on ESR (DAS28-ESR), rheumatoid factor (RF) and anticyclic citrullinated peptide antibodies (ACPAs). The study included 129 patients with RA and 83 healthy controls. Serum IL-35 levels were detected by ELISA. ESR and CRP were measured by the Westergren method and the immune transmission turbidity method, respectively. RF and ACPA were measured using immunoturbidimetric assays and chemiluminescence analysis, respectively. The results showed that serum IL-35 levels were elevated in patients with RA. Univariate and multivariate analyses showed that the high serum IL-35 levels were correlated with low ESR and DAS28-ESR. These suggested that IL-35, an important anti-inflammatory cytokine, may participate in the regulation of the pathogenesis of RA, especially with disease activity.