PT  - JOURNAL ARTICLE
AU  - ZQ Hao
AU  - WD Zhan
AU  - YF Tang
AU  - YJ Wang
TI  - 11 Tissue vaporization mechanism in photoselective vaporization of the prostate based on EDFA
AID  - 10.1136/jim-2019-000994.11
DP  - 2019 Mar 01
TA  - Journal of Investigative Medicine
PG  - A4--A4
VI  - 67
IP  - Suppl 1
4099  - http://hw-f5-jim.highwire.org/content/67/Suppl_1/A4.1.short
4100  - http://hw-f5-jim.highwire.org/content/67/Suppl_1/A4.1.full
SO  - J Investig Med2019 Mar 01; 67
AB  - Background To develop a more efficient scheme in photoselective vaporization of the prostate (PVP) with fewer side effects, as well as to determine the critical time of tissue coagulation or vaporization and the degree of thermal damage of the tissue, the tissue vaporization mechanism in photoselective vaporization of the prostate based on EDFA was analyzed.Methods By comparing the laser vaporization effect of animal liver tissue, muscle tissue and prostate tissue, a laser operation scheme based on EDFA was proposed. The 1064 nm laser is used as the light source, whose power is amplified by EDFA, and the 532 nm laser is obtained by frequency doubling of KTP, which has higher vaporization efficiency and less thermal damage in PVP operation.Results When the output power of the system is 48.9 W, the frequency is 50 Hz, the pulse width is 5 ms, and the action time is 10 s. In dog prostate samples, the vaporization pit with diameters of 2.0 mm and 3.5 mm, respectively, are produced in aqueous and air conditions, and the thermal damage thickness is 0.4 mm and 0.8 mm.Conclusion The experimental results show that the establishment of the system is of great significance for the study of the tissue vaporization mechanism and provides a valuable reference for further improvement of PVP operation.Acknowledgements Supported by a project from Jilin Science and Technology Department (Project No.20170204079GX).