PT  - JOURNAL ARTICLE
AU  - Michael Sponder
AU  - Michael Lichtenauer
AU  - Bernhard Wernly
AU  - Vera Paar
AU  - Uta Hoppe
AU  - Michael Emich
AU  - Monika Fritzer-Szekeres
AU  - Brigitte Litschauer
AU  - Jeanette Strametz-Juranek
TI  - Serum heart-type fatty acid-binding protein decreases and soluble isoform of suppression of tumorigenicity 2 increases significantly by long-term physical activity
AID  - 10.1136/jim-2018-000913
DP  - 2019 Jun 01
TA  - Journal of Investigative Medicine
PG  - 833--840
VI  - 67
IP  - 5
4099  - http://hw-f5-jim.highwire.org/content/67/5/833.short
4100  - http://hw-f5-jim.highwire.org/content/67/5/833.full
SO  - J Investig Med2019 Jun 01; 67
AB  - The aim of this prospective study was to investigate the influence of long-term physical activity on biomarkers for myocyte ischemia (heart-type fatty acid-binding protein, H-FABP), matrix remodelling/vascular stress (soluble isoform of suppression of tumorigenicity 2, sST2) and inflammation (soluble urokinase-type plasminogen activator receptor, suPAR). In this prospective observational study 109 subjects were recruited, 98 completed the study. Subjects were asked to perform exercise within the calculated training pulse for 8 months. The performance gain was measured/quantified by bicycle stress tests at the beginning and end of the observation period. Twenty-seven subjects with a performance gain <2.9% were excluded. suPAR, H-FABP and sST2 were measured in serum at baseline and after 2, 4 and 8 months by ELISA. We found a significant decrease in H-FABP (1.86 (0.86) to 1.29 (0.98) ng/mL; p<0.01) and a significant increase in sST2 levels (6126 (2759) to 6919 (3720) pg/mL; p=0.045) during the observation period of 8 months while there was no remarkable change in suPAR levels. We interpret the activity-induced decrease in H-FABP as sign of lower subclinical myocardial ischemia and better perfusion, probably due to a more economic metabolization and electrolyte balance. The increase in sST2 might reflect physiological sports-induced vascular stress. As H-FABP and sST2 play an important role in the pathomechanism of ischemic cardiomyopathy (iCMP) further studies should investigate the influence of regular physical activity on these biomarkers in a population of patients with iCMP.Trial registration number NCT02097199.