TY - JOUR T1 - Alzheimer’s disease: many failed trials, so where do we go from here? JF - Journal of Investigative Medicine JO - J Investig Med SP - 1135 LP - 1140 DO - 10.1136/jim-2020-001297 VL - 68 IS - 6 AU - Allison Bethanne Reiss AU - Amy D Glass AU - Thomas Wisniewski AU - Benjamin Wolozin AU - Irving H Gomolin AU - Aaron Pinkhasov AU - Joshua De Leon AU - Mark M Stecker Y1 - 2020/08/01 UR - http://hw-f5-jim.highwire.org/content/68/6/1135.abstract N2 - Alzheimer’s disease (AD) is a neurodegenerative brain disorder associated with relentlessly progressive cognitive impairment and memory loss. AD pathology proceeds for decades before cognitive deficits become clinically apparent, opening a window for preventative therapy. Imbalance of clearance and buildup of amyloid β and phosphorylated tau proteins in the central nervous system is believed to contribute to AD pathogenesis. However, multiple clinical trials of treatments aimed at averting accumulation of these proteins have yielded little success, and there is still no disease-modifying intervention. Here, we discuss current knowledge of AD pathology and treatment with an emphasis on emerging biomarkers and treatment strategies. ER -