RT Journal Article
SR Electronic
T1 Gout as a risk factor for acute myocardial infarction: evidence from competing risk model analysis
JF Journal of Investigative Medicine
JO J Investig Med
FD BMJ Publishing Group Ltd
SP 1161
OP 1167
DO 10.1136/jim-2020-001714
VO 69
IS 6
A1 Chia-Luen Huang
A1 Tai-Wen Wang
A1 Yong-Chen Chen
A1 Je-Ming Hu
A1 Po-Ming Ku
A1 Chang-Hsun Hsieh
A1 Chien-Hsing Lee
A1 Feng-Chih Kuo
A1 Chieh-Hua Lu
A1 Cheng-Chiang Su
A1 Jhih-Syuan Liu
A1 Fu-Huang Lin
A1 Yu-Ching Chou
A1 Chien-An Sun
YR 2021
UL http://hw-f5-jim.highwire.org/content/69/6/1161.abstract
AB Chronic inflammation, a hallmark of gout, is implicated in the pathogenesis of atherosclerosis. Thus, in theory, gout can be expected to increase the risk of acute myocardial infarction (AMI). Yet, results from several epidemiological studies have been inconclusive. A retrospective cohort study was conducted using the National Health Insurance Research Database of Taiwan dated from 2000 to 2013. The study cohort comprised 3581 patients with gout (the gout cohort) and 14,324 patients without gout (the non-gout cohort). The primary outcome was the incidence of AMI. To estimate the effect of gout on the risk of AMI, the Lunn-McNeil competing risk model was fitted to estimate cause-specific hazard ratios (HRs) and their 95% confidence intervals (CIs). The cumulative incidence of AMI was significantly higher in the gout cohort than in the non-gout cohort, resulting in an adjusted HR of 1.36 (95% CI 1.04 to 2.76). Further, HRs of gout with incident AMI were higher in patients without hypertension, diabetes mellitus, or hyperlipidemia (ranging from 1.63 to 2.09) than in those with each of these comorbidities (ranging from 0.95 to 1.13). The results of this study suggest that patients with gout have an increased risk of AMI. The AMI risk associated with gout was conditional on patients’ cardiovascular risk profile. Future work is needed to confirm these findings.No data are available.