PT - JOURNAL ARTICLE AU - Chi-Feng Pan AU - Shih-Ming Chuang AU - Kuan-Chia Lin AU - Ming-Chieh Tsai AU - Wei-Tsen Liao AU - Yi-Hong Zeng AU - Chun-Chuan Lee TI - Risk associated with estimated glomerular filtration rate and albuminuria for PAD among patients with type 2 diabetes AID - 10.1136/jim-2021-001786 DP - 2021 Aug 01 TA - Journal of Investigative Medicine PG - 1182--1188 VI - 69 IP - 6 4099 - http://hw-f5-jim.highwire.org/content/69/6/1182.short 4100 - http://hw-f5-jim.highwire.org/content/69/6/1182.full SO - J Investig Med2021 Aug 01; 69 AB - Chronic kidney disease (CKD) is significantly associated with peripheral arterial disease (PAD) in some studies, but data on the association of the risk of PAD across a broad range of kidney function in patients with type 2 diabetes are limited. Between October 17, 2013 and February 7, 2015, all consecutive outpatients with type 2 diabetes underwent ankle-brachial index (ABI) examination. We investigated the association of estimated glomerular filtration rate (eGFR) and albumin-to-creatinine ratio (ACR) with the risk of PAD. A total of 1254 patients were cross-classified into 12 groups based on ACR category (normoalbuminuria, microalbuminuria and macroalbuminuria) and eGFR stage (≥90, 60–89, 30–59 and <30 mL/min/1.73 m2). Logistic regression analysis was used to investigate the association of eGFR and ACR with PAD. Within each ACR category, a lower eGFR stage was associated with PAD. Similarly, within each eGFR group, a higher ACR category was also associated with PAD. The OR for PAD was highest in patients with eGFR <30 mL/min/1.73 m2 and macroalbuminuria (OR 14.42, 95% CI 4.60 to 45.31) when compared with the reference group of subjects with eGFR ≥90 mL/min/1.73 m2 and normoalbuminuria. Our study found that cross-classification of eGFR with ACR revealed a more comprehensive association with risk of PAD than eGFR or ACR alone.The data used to support the findings of this study are available from the corresponding author upon request.