PT  - JOURNAL ARTICLE
AU  - Mengying Tong
AU  - Shuang Li
AU  - Yulong Li
AU  - Ying Li
AU  - Yue Feng
AU  - Ying Che
TI  - Tumor invasive ability of papillary thyroid carcinomas is not conferred by acquired gene mutations
AID  - 10.1136/jim-2021-001971
DP  - 2021 Oct 01
TA  - Journal of Investigative Medicine
PG  - 1382--1385
VI  - 69
IP  - 7
4099  - http://hw-f5-jim.highwire.org/content/69/7/1382.short
4100  - http://hw-f5-jim.highwire.org/content/69/7/1382.full
SO  - J Investig Med2021 Oct 01; 69
AB  - Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. The ability to predict whether a carcinoma would exhibit invasive ability in patients with PTC is important and has clinical implications for the selection of therapeutic strategies. Although several studies have focused on the genetic characterization of invasive cancer cells, the factors critical to the origination of invasive cancer cells are still unclear. This study aimed to determine whether genomic mutations contribute to the acquisition of the tumor invasion phenotype and to investigate the genetic features of invasive cancer cells in patients with PTC. We performed customized 48-gene deep exon sequencing in samples obtained from 88 patients with PTC via fine needle aspiration; the results revealed that no genetic changes were specifically associated with the tumor aggressiveness phenotype. Our results indicate that genetic mutations do not cause indolent PTCs to become invasive.