RT Journal Article
SR Electronic
T1 Tumor invasive ability of papillary thyroid carcinomas is not conferred by acquired gene mutations
JF Journal of Investigative Medicine
JO J Investig Med
FD BMJ Publishing Group Ltd
SP 1382
OP 1385
DO 10.1136/jim-2021-001971
VO 69
IS 7
A1 Mengying Tong
A1 Shuang Li
A1 Yulong Li
A1 Ying Li
A1 Yue Feng
A1 Ying Che
YR 2021
UL http://hw-f5-jim.highwire.org/content/69/7/1382.abstract
AB Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. The ability to predict whether a carcinoma would exhibit invasive ability in patients with PTC is important and has clinical implications for the selection of therapeutic strategies. Although several studies have focused on the genetic characterization of invasive cancer cells, the factors critical to the origination of invasive cancer cells are still unclear. This study aimed to determine whether genomic mutations contribute to the acquisition of the tumor invasion phenotype and to investigate the genetic features of invasive cancer cells in patients with PTC. We performed customized 48-gene deep exon sequencing in samples obtained from 88 patients with PTC via fine needle aspiration; the results revealed that no genetic changes were specifically associated with the tumor aggressiveness phenotype. Our results indicate that genetic mutations do not cause indolent PTCs to become invasive.