@article {Qu363, author = {Jian-Feng Qu and Huo-Hua Zhong and Wen-Cong Liang and Yang-Kun Chen and Yong-Lin Liu and Wei Li}, title = {Neuroimaging risk factors for participation restriction after acute ischemic stroke: 1-year follow-up study}, volume = {70}, number = {2}, pages = {363--368}, year = {2022}, doi = {10.1136/jim-2020-001675}, publisher = {BMJ Publishing Group Limited}, abstract = {The aim of the present study was to determine the neuroimaging predictors of poor participation after acute ischemic stroke. A total of 443 patients who had acute ischemic stroke were assessed. At 1-year recovery, the Reintegration to Normal Living Index was used to assess participation restriction. We also assessed the Activities of Daily Living Scale and modified Rankin Scale (mRS) score. Brain MRI measurement included acute infarcts and pre-existing abnormalities such as enlarged perivascular spaces, white matter lesions, ventricular-brain ratio, and medial temporal lobe atrophy (MTLA). The study included 324 men (73.1\%) and 119 women (26.9\%). In the univariate analysis, patients with poor participation after 1 year were older, more likely to be men, had higher National Institutes of Health Stroke Scale (NIHSS) score on admission, with more histories of hypertension and atrial fibrillation, larger infarct volume, more severely enlarged perivascular spaces and MTLA, and more severe periventricular hyperintensities and deep white matter hyperintensities. Patients with participation restriction also had poor activities of daily living (ADL) and mRS score. Multiple logistic regression showed that, in model 1, age, male gender, NIHSS score on admission, and ADL on follow-up were significant predictors of poor participation, accounting for 60.2\% of the variance. In model 2, which included both clinical and MRI variables, male gender, NIHSS score on admission, ADL on follow-up, and MTLA were significant predictors of poor participation, accounting for 61.2\% of the variance. Participation restriction was common after acute ischemic stroke despite good mRS score. Male gender, stroke severity, severity of ADL on follow-up, and MTLA may be predictors of poor participation.Trial registration number ChiCTR1800016665.All data relevant to the study are included in the article or uploaded as supplementary information. All data generated or analyzed during this study are included in this published article.}, issn = {1081-5589}, URL = {http://hw-f5-jim.highwire.org/content/70/2/363}, eprint = {http://hw-f5-jim.highwire.org/content/70/2/363.full.pdf}, journal = {Journal of Investigative Medicine} }