TY - JOUR T1 - Cardiac safety and clinical efficacy of high-dose domperidone for long-term treatment of gastroparesis symptoms JF - Journal of Investigative Medicine JO - J Investig Med SP - 1225 LP - 1232 DO - 10.1136/jim-2021-001968 VL - 70 IS - 5 AU - Kevin Woods AU - Mahesh Gajendran AU - Zorisadday Gonzalez AU - Marco Bustamante-Bernal AU - Irene Sarosiek AU - Karina Espino AU - Nathan Waterhouse AU - Tariq Siddiqui AU - Richard McCallum Y1 - 2022/06/01 UR - http://hw-f5-jim.highwire.org/content/70/5/1225.abstract N2 - Domperidone is an effective antiemetic used worldwide, but there have been reports of possible cardiotoxicity. Our goal was to explore the cardiac safety and clinical efficacy of long-term domperidone, titrated as high as 120 mg/day, in patients not responding or unable to tolerate other therapies for gastroparesis (GP).This retrospective cohort study was conducted at a single tertiary care academic center. We objectively assessed the safety and efficacy of domperidone through questionnaires, clinical follow-up and frequent ECGs as mandated by the Food and Drug Administration. We excluded patients with a history of dangerous arrhythmias, prolonged QTc, clinically significant electrolyte disturbances, gastrointestinal hemorrhage or obstruction, presence of a prolactinoma, pregnant or breastfeeding females, or allergy to domperidone. A total of 21 patients met the inclusion criteria for eligibility in this study (52.4% white, 42.9% Hispanic; mean age 50.1 years; 90.5% female). The mean duration of domperidone therapy was 52.3 (range 16–97) months with a mean highest dose of 80 mg/day (range 40–120 mg). Two patients (9.5%) taking 120 mg/day experienced asymptomatic meaningful QTc prolongation (>450 ms in males, >470 ms in females). One-third of patients had asymptomatic non-meaningful QTc prolongation. Palpitations or chest pain was reported in 19% of patients without ECG abnormalities or adverse cardiac events. The mean severity of vomiting and nausea was improved by 82% and 55%, respectively.Long-term treatment with high doses of domperidone (40–120 mg/day) improved GP symptoms in patients previously refractory to other medical therapies and with a satisfactory cardiovascular risk profile.Data are available upon reasonable request. All data relevant to the study are included in the article or uploaded as supplementary information. ER -