RT Journal Article SR Electronic T1 Process analysis of anthracycline adverse reactions in breast cancer patients with postoperative chemotherapy JF Journal of Investigative Medicine JO J Investig Med FD BMJ Publishing Group Ltd SP 1352 OP 1357 DO 10.1136/jim-2022-002339 VO 70 IS 6 A1 Chang Liu A1 Binglu Cheng A1 Gang Zhao A1 Hengjie Yuan YR 2022 UL http://hw-f5-jim.highwire.org/content/70/6/1352.abstract AB This study aimed to explore the clinical adverse effects of anthracyclines on patients undergoing chemotherapy after breast cancer surgery. A total of 118 patients who received anthracycline chemotherapy after breast cancer surgery were selected as the research object, and the changes of echocardiogram, ECG, myocardial enzymes and blood biochemical indices before, during and after chemotherapy were studied. SPSS V.20 was used to conduct statistical analysis. The differences in heart rate, ST-segment abnormalities, creatine kinase, lactate dehydrogenase, hemoglobin, albumin, triglycerides and high-density lipoprotein were statistically significant. Heart rate and triglycerides increased significantly in the early stage of chemotherapy; ST-segment abnormality increased during the entire chemotherapy period; creatine kinase and lactate dehydrogenase increased significantly in the late stage of chemotherapy; hemoglobin and albumin decreased in the early stage of chemotherapy. The magnitude is large; high-density lipoprotein decreases throughout the chemotherapy period. In anthracycline chemotherapy regimens, bone marrow suppression and dyslipidemia occur in the early stage of chemotherapy, and the risk of cardiotoxicity is higher in the late stage of chemotherapy.Data are available upon reasonable request.