PT  - JOURNAL ARTICLE
AU  - Xiaojuan Fan
AU  - Xiaoke Wang
AU  - Jianqing She
AU  - Xiaoqian Niu
AU  - Yongbai Luo
AU  - Wen Xi
AU  - Tao Zheng
AU  - Yue Wu
TI  - Higher serum triglyceride can predict recurrent coronary revascularization events in patients undergoing percutaneous coronary intervention with baseline LDL-C <55 mg/dL
AID  - 10.1136/jim-2022-002401
DP  - 2022 Sep 02
TA  - Journal of Investigative Medicine
PG  - jim-2022-002401
4099  - http://hw-f5-jim.highwire.org/content/early/2022/09/01/jim-2022-002401.short
4100  - http://hw-f5-jim.highwire.org/content/early/2022/09/01/jim-2022-002401.full
AB  - Patients with low baseline low-density lipoprotein cholesterol (LDL-C) but experiencing recurrent coronary revascularization events have been rarely investigated. In this retrospective cohort study, we enrolled patients undergoing percutaneous coronary intervention (PCI) with baseline LDL-C <55 mg/dL at the First Affiliated Hospital of Xi’an Jiaotong University between January and December 2017. Subsequent ischemia-driven coronary revascularization events and all-cause death were documented during a 4-year follow-up. Cox analysis was used to evaluate the association between baseline clinical characteristics and long-term events. As a result, among 388 patients (mean age 63 years; 79.1% male) enrolled, 32 patients underwent recurrent revascularization events, and 38 patients occurred all-cause death. After adjustment for age, diabetes mellitus, multi-vessel disease, and lipoprotein(a), multivariate Cox analysis showed that baseline serum triglyceride (TG) (HR 1.691, 95% CI 1.178 to 2.428, p=0.004) was an independent predictor of recurrent coronary revascularization events. Kaplan-Meier analysis revealed that a higher TG level (≥1.17 mmol/L, determined by receiver operating characteristic curve) was associated with increased risk of recurrent revascularization events than lower TG level (<1.17 mmol/L) (p=0.021). Female (HR 2.647, 95% CI 1.350 to 5.190, p=0.005) and previous atrial fibrillation (HR 3.163, 95% CI 1.403 to 7.132, p=0.006) were associated with increased risk of all-cause death. In conclusion, for patients undergoing PCI with baseline LDL-C <55 mg/dL, higher baseline TG can predict recurrent coronary revascularization events.Data are available on reasonable request. Data are available from the corresponding author on reasonable request.