PT - JOURNAL ARTICLE AU - Mathieu Blot AU - Abdeljalil Zeggay AU - Ludwig-Serge Aho-Glele AU - Caroline Laborde AU - Vincent Le Moing AU - Catherine Chirouze AU - Kevin Bouiller AU - Lionel Piroth TI - Is blood lymphocyte count a prognostic biomarker in <em>Staphylococcus aureus</em> bacteremia? AID - 10.1136/jim-2022-002356 DP - 2022 Oct 01 TA - Journal of Investigative Medicine PG - 1549--1552 VI - 70 IP - 7 4099 - http://hw-f5-jim.highwire.org/content/70/7/1549.short 4100 - http://hw-f5-jim.highwire.org/content/70/7/1549.full SO - J Investig Med2022 Oct 01; 70 AB - Lymphopenia is common in patients with sepsis and associated with mortality. Immune-stimulatory therapies likely to restore T-cells count and function are under investigation in sepsis. Our study aimed to assess whether lymphopenia is a reliable prognostic biomarker in Staphylococcus aureus bacteremia. We conducted an ancillary study of the prospective VIRSTA Study including 574 patients with S. aureus bacteremia in two tertiary care centers. Neither lymphocyte count at the onset nor lymphocyte change during the first 4 days was associated with 12-week mortality. These results highlight the importance of characterizing the immune profile of patients with sepsis according to the cause before investigating immunostimulatory therapies to restore lymphocyte proliferation and function.