RT Journal Article
SR Electronic
T1 Is blood lymphocyte count a prognostic biomarker in <em>Staphylococcus aureus</em> bacteremia?
JF Journal of Investigative Medicine
JO J Investig Med
FD BMJ Publishing Group Ltd
SP 1549
OP 1552
DO 10.1136/jim-2022-002356
VO 70
IS 7
A1 Mathieu Blot
A1 Abdeljalil Zeggay
A1 Ludwig-Serge Aho-Glele
A1 Caroline Laborde
A1 Vincent Le Moing
A1 Catherine Chirouze
A1 Kevin Bouiller
A1 Lionel Piroth
YR 2022
UL http://hw-f5-jim.highwire.org/content/70/7/1549.abstract
AB Lymphopenia is common in patients with sepsis and associated with mortality. Immune-stimulatory therapies likely to restore T-cells count and function are under investigation in sepsis. Our study aimed to assess whether lymphopenia is a reliable prognostic biomarker in Staphylococcus aureus bacteremia. We conducted an ancillary study of the prospective VIRSTA Study including 574 patients with S. aureus bacteremia in two tertiary care centers. Neither lymphocyte count at the onset nor lymphocyte change during the first 4 days was associated with 12-week mortality. These results highlight the importance of characterizing the immune profile of patients with sepsis according to the cause before investigating immunostimulatory therapies to restore lymphocyte proliferation and function.