RT Journal Article SR Electronic T1 Acute myocardial infarction and concomitant acute intracranial hemorrhage: clinical characteristics and outcomes JF Journal of Investigative Medicine JO J Investig Med FD BMJ Publishing Group Ltd SP 1713 OP 1719 DO 10.1136/jim-2022-002334 VO 70 IS 8 A1 Xiangqi Cao A1 Meng Wei A1 Manyun Tang A1 Zhijie Jian A1 Hui Liu A1 Xin Yue A1 Guogang Luo A1 Chaofeng Sun A1 Fengwei Guo YR 2022 UL http://hw-f5-jim.highwire.org/content/70/8/1713.abstract AB This study aimed to evaluate the demographic and clinical characteristics, treatments and outcomes of concomitant acute myocardial infarction (AMI) and acute intracranial hemorrhage (ICH). All patients diagnosed with concomitant AMI and acute ICH admitted to our institution were included retrospectively. The patient demographics, clinical characteristics, neuroimaging and treatment approaches were analyzed, and the outcomes of interest included disability as defined by the modified Rankin Scale (mRS) score and all-cause mortality within 1 year of follow-up. Of a total of 4972 patients with AMI, 8 patients (0.2%) with concomitant acute ICH were recruited for the study, including ST-segment elevation myocardial infarction (STEMI, 5 cases) and non-STEMI (3 cases). New-onset acute ICH in 4 of the 5 patients (80%) occurred within 24 hours after the AMI event, and all these patients had a sudden decrease in the level of consciousness, with an average decrease of 4.6 on the Glasgow Coma Scale. All 5 out of 8 patients had irregular shapes and uncommon sites of hematoma presentation documented on CT scans. Unfortunately, 2 patients died from a progression of ICH within 1 week, and 2 of the 6 survivors had poor functional outcomes (mRS ≥3) at the 1-year follow-up. Concomitant acute ICH and AMI are rare complications displaying unique iconography. Acute ICH caused serious prejudice in AMI with higher mortality and poor functional outcomes, and cardiac catheterization without the administration of antithrombotic or antiplatelet agents was feasible for patients who had unstable hemodynamics or STEMI.Data are available upon reasonable request.