PT - JOURNAL ARTICLE AU - Arash Rafeeinia AU - Gholamreza Asadikaram AU - Mehrnaz Karimi-Darabi AU - Moslem Abolhassani AU - Mojtaba Abbasi-Jorjandi AU - Vahid Moazed TI - Organochlorine pesticides, oxidative stress biomarkers, and leukemia: a case-control study AID - 10.1136/jim-2021-002289 DP - 2022 Dec 01 TA - Journal of Investigative Medicine PG - 1736--1745 VI - 70 IP - 8 4099 - http://hw-f5-jim.highwire.org/content/70/8/1736.short 4100 - http://hw-f5-jim.highwire.org/content/70/8/1736.full SO - J Investig Med2022 Dec 01; 70 AB - Exposure to pesticides has been linked to an elevated risk of leukemia. The present research aimed to evaluate the relationship between organochlorine (OC) pesticides and biomarkers of oxidative stress in patients with leukemia. This work was conducted on 109 patients with leukemia and 109 healthy controls. The serum concentrations of seven derivatives of OCs including alpha-hexachlorocyclohexane (HCH), beta-HCH, gamma-HCH, 2,4-dichlorodiphenyltrichloroethane (DDT), 4,4-DDT, 2,4-dichlorodiphenyldichloroethylene (DDE), and 4,4-DDE along with acetylcholinesterase (AChE), glutathione peroxidase (GPx), superoxide dismutase (SOD), paraoxonase-1 (PON1), and catalase (CAT) activities as well as total antioxidant capacity (TAC), nitric oxide (NO), protein carbonyl (PC), and malondialdehyde (MDA) levels were measured in all the subjects. Levels of OCs were remarkably higher in patients with leukemia compared with the controls (p<0.05). In addition, levels of SOD, AChE, GPx, PON1, and TAC were remarkably lower in patients with leukemia compared with controls (p<0.05). In contrast, MDA, NO, and PC concentrations were higher in patients with leukemia than in the controls (p<0.05). Moreover, the serum level of 4,4-DDE was negatively associated with GPx activity (p=0.038). Our findings suggest that OCs may play a role in the development of leukemia by disrupting the oxidant/antioxidant balance.No data are available.