RT Journal Article
SR Electronic
T1 FTO First Intron rs1558902 Variant and Platelets Count in White Middle-aged Women
JF Journal of Investigative Medicine
JO J Investig Med
FD BMJ Publishing Group Ltd
SP 291
OP 293
DO 10.2310/JIM.0b013e31827b9994
VO 61
IS 2
A1 Jaroslav A. Hubacek
A1 Dana Dlouha
A1 Vera Lanska
A1 Petr Stavek
A1 Libuse Pagacova
A1 Ivana Kralova-Lesna
A1 Jan Pitha
YR 2013
UL http://hw-f5-jim.highwire.org/content/61/2/291.abstract
AB The polymorphisms within the FTO gene play an important role in the genetic determination of body weight and body mass index and have been associated with cardiovascular disease, but the causal mechanism is still a matter of debate. The possible effect on the platelet count as a marker of hemocoagulation status as a possible cardiovascular risk factor was suggested in Japanese population. We have analyzed both rs1558902 FTO polymorphism (T > A) and platelet counts in the Prague Pre and Post Menopausal Females (3PMFs) study, including those of 669 women (mean age, 55.7 ± 2.7 years). The frequencies of the FTO genotypes were similar to other populations (TT, 30.4%; TA, 48.1%; and AA, 21.5%). We have not detected a significant association between the FTO rs1558902 variant and platelet counts in white women (TT, 242 ± 55 × 109; TA, 246 ± 67 × 109; and AA, 247 ± 55 × 109; F[2.642] = 0.30, P = 0.75). At least in white persons, platelet count seems not to be a link between the FTO variation and risk of cardiovascular disease.