TY - JOUR T1 - FTO Gene Polymorphisms and Platelet Counts in a General Japanese Population JF - Journal of Investigative Medicine JO - J Investig Med SP - 514 LP - 516 DO - 10.2310/JIM.0b013e318240527c VL - 60 IS - 2 AU - Kazuhiko Kotani AU - Shinji Fujiwara AU - Kokoro Tsuzaki AU - Naoki Sakane Y1 - 2012/02/01 UR - http://hw-f5-jim.highwire.org/content/60/2/514.abstract N2 - The fat mass and obesity-associated (FTO) gene has recently attracted attention as one of the obesity-related genes. Obesity-related gene polymorphisms may be associated with the development of atherothrombosis in relation to platelets. The present study investigated the association between FTO gene polymorphisms (rs1558902, T/A) and hematological parameters, in particular the platelet counts. Anthropometric, hematological, and biochemical parameters, in addition to genotyping by an allele-specific DNA assay, were measured in 209 asymptomatic community-dwelling Japanese subjects (male/female: 80/129; mean age, 65 years; mean [SD] body mass index, 24.0 [3.0] kg/m2). The subjects with the A-allele (n = 73) showed significantly higher platelet counts than those without the A-allele (mean [SD], 237 [58] vs 217 [57] × 109/L, P < 0.05). Even when multiple-adjusted analyses were performed, the platelet counts continued to differ significantly and independently of other variables, including obesity-related parameters such as the index of insulin resistance or high-sensitivity C-reactive protein, between the subjects with and without the A-allele. The FTO gene polymorphisms may be associated with the minor but significant modulation of platelet counts in this population. ER -