RT Journal Article
SR Electronic
T1 Oxidative challenge in Alzheimer's disease: state of knowledge and future needs
JF Journal of Investigative Medicine
JO J Investig Med
FD BMJ Publishing Group Ltd
SP 21
OP 32
DO 10.1136/jim-2015-000017
VO 64
IS 1
A1 Carlo Cervellati
A1 Paul L Wood
A1 Arianna Romani
A1 Giuseppe Valacchi
A1 Monica Squerzanti
A1 Juana Maria Sanz
A1 Beatrice Ortolani
A1 Giovanni Zuliani
YR 2016
UL http://hw-f5-jim.highwire.org/content/64/1/21.abstract
AB A large body of experimental and postmortem findings indicate that Alzheimer's disease (AD) is associated with increased oxidative stress (OxS) levels in the brain. Despite the current limitations of OxS assessment in living subjects, recent data suggest that oxidative challenge might increase early both in the central nervous system and peripheral fluids. The aim of this review was to provide an overview of the existing literature linking systemic OxS to brain OxS in AD. We firmly believe that continued research aimed at overcoming the methodological and design issues affecting the body of studies in this field is mandatory for successful development of an effective antioxidant-based treatment of AD.