TY - JOUR T1 - Western Regional Meeting 2016, Carmel, California, January 28–30, 2016 JF - Journal of Investigative Medicine JO - J Investig Med SP - 299 LP - 345 DO - 10.1136/jim-d-15-00013.378 VL - 64 IS - 1 A2 - , Y1 - 2016/01/01 UR - http://hw-f5-jim.highwire.org/content/64/1/299.abstract N2 - 378: A CLOSE LOOK AT THE USE OF HYPERTONIC SALINE AND HIGH FLOW OXYGEN IN PEDIATRIC PATIENTS HOSPITALIZED WITH RESPIRATORY SYNCYTIAL VIRUSC Mercurio1J Green2,1B Afghani1,21UC Irvine, Irvine, CA2Children's Hospital of Orange County, Orange, CAPurpose of Study Use of hypertonic saline (HS) and high flow nasal cannula oxygen (HFNC) has become more prevalent in pediatric patients hospitalized with espiratory syncytial virus (RSV). However, published literature on their use is limited. The objective of our study is review the use of hypertonic saline and high flow oxygen in infants hospitalized with RSV.Methods Used We performed a retrospective chart review of pediatric patients less <1 year of age who were hospitalized at Children's Hospital of Orange County during the 2013–14 RSV season with a diagnosis of RSV. We documented the management regimen, with a particular look at the use of HS and HFNC. 165 patients less <1 year of age fulfilled our inclusion criteria. 6 patients were omitted from data analysis due to incomplete outside records.Summary of Results For patients <2 months of age, 9 (53%) of 17 with underlying conditions vs. 39 (66%) of 59 patients without underlying conditions required HS (P=0.3956). Although it didn't meet statistical significance, it seems that the use of HFNC tended to be more frequent in patients <2 months of age with underlying conditions (29% vs. 10%, P=0.062). Use of HFNC or HS was not different for those >2 months of age with or without underlying conditions. The mean length of stay (LOS) for different types of treatment is summarized in the table below.Conclusions Our study shows that the use of HFNC tended to be more frequent in young infants with an underlying condition. The use of HFNC or HS was associated with longer LOS. Large prospective studies that take into account severity of illness, underlying conditions and differing protocols for use of HFNC and HS … ER -