RT Journal Article
SR Electronic
T1 Crosstalk between toll-like receptors and hypoxia-dependent pathways in health and disease
JF Journal of Investigative Medicine
JO J Investig Med
FD BMJ Publishing Group Ltd
SP jim-d-15-00131
DO 10.1097/JIM.0000000000000228
A1 Bianca Crifo
A1 Cormac T Taylor
YR 2016
UL http://hw-f5-jim.highwire.org/content/early/2016/01/08/JIM.0000000000000228.abstract
AB Toll-like receptors (TLRs) play an important role in shaping the host immune response to infection and inflammation. Tissue hypoxia is a common microenvironmental feature of infected and inflamed tissues. Furthermore, hypoxia significantly impacts the development of immune and inflammatory responses through the regulation of host innate and adaptive immunity. Here, we will discuss current knowledge in relation to the crosstalk that exists between toll-like receptor- and hypoxia-dependent signaling pathways in health and disease.