RT Journal Article
SR Electronic
T1 Targeting hypoxia in inflammatory bowel disease
JF Journal of Investigative Medicine
JO J Investig Med
FD BMJ Publishing Group Ltd
SP 364
OP 368
DO 10.1097/JIM.0000000000000218
VO 64
IS 2
A1 Sean P Colgan
YR 2016
UL http://hw-f5-jim.highwire.org/content/64/2/364.abstract
AB In this review, I summarize some of the recent insight into pharmacological targeting of hypoxia in disease models. Studies from cultured cell systems, animal models, and translation to human patients have revealed that posttranslational modifications of individual proteins within NF-κB and hypoxia-inducible factor pathways serve as ideal targets for analysis in disease models. Studies defining differences and similarities between these responses have taught us a number of important lessons about the complexity of the inflammatory response. A clearer definition of these pathways has provided new insight into disease pathogenesis and, importantly, the potential for new therapeutic targets.