PT  - JOURNAL ARTICLE
AU  - Bianca Crifo
AU  - Cormac T Taylor
TI  - Crosstalk between toll-like receptors and hypoxia-dependent pathways in health and disease
AID  - 10.1097/JIM.0000000000000228
DP  - 2016 Feb 01
TA  - Journal of Investigative Medicine
PG  - 369--375
VI  - 64
IP  - 2
4099  - http://hw-f5-jim.highwire.org/content/64/2/369.short
4100  - http://hw-f5-jim.highwire.org/content/64/2/369.full
SO  - J Investig Med2016 Feb 01; 64
AB  - Toll-like receptors (TLRs) play an important role in shaping the host immune response to infection and inflammation. Tissue hypoxia is a common microenvironmental feature of infected and inflamed tissues. Furthermore, hypoxia significantly impacts the development of immune and inflammatory responses through the regulation of host innate and adaptive immunity. Here, we will discuss current knowledge in relation to the crosstalk that exists between toll-like receptor- and hypoxia-dependent signaling pathways in health and disease.