%0 Journal Article %A Amani Beshara %A Eytan Cohen %A Elad Goldberg %A Pearl Lilos %A Moshe Garty %A Ilan Krause %T Triglyceride levels and risk of type 2 diabetes mellitus: a longitudinal large study %D 2016 %R 10.1136/jim-2015-000025 %J Journal of Investigative Medicine %P 383-387 %V 64 %N 2 %X The relationship between triglyceridemia and diabetes mellitus remains unclear. This study evaluated the risk of diabetes and impaired fasting glucose associated with a wide range of triglyceride levels. A longitudinal retrospective study was carried out employing data from a screening center between the years 2000 and 2012. Inclusion criteria were absence of diabetes at baseline and attendance at the center at least twice over a 5-year period. Participants were divided by fasting blood glucose level (normal/impaired) at the first visit. A total of 5085 participants were eligible for the study. Of the 4164 normoglycemic participants at baseline, 40 (0.96%) had diabetes and 998 (24%) had impaired fasting glucose by the end of the study. On stepwise logistic regression analysis, every 10 mg/dL increase in triglyceride level significantly increased the risk of diabetes by 4% and of impaired fasting glucose by 2% (p<0.001). This association held true even when rising triglyceride levels remained within the accepted normal range (<150 mg/dL, p<0.001). Sustained increments in serum triglyceride level, even within the accepted normal range, are an independent risk factor for diabetes mellitus and impaired fasting glucose in normoglycemic participants. %U http://hw-f5-jim.highwire.org/content/jim/64/2/383.full.pdf