PT  - JOURNAL ARTICLE
AU  - Beshara, Amani
AU  - Cohen, Eytan
AU  - Goldberg, Elad
AU  - Lilos, Pearl
AU  - Garty, Moshe
AU  - Krause, Ilan
TI  - Triglyceride levels and risk of type 2 diabetes mellitus: a longitudinal large study
AID  - 10.1136/jim-2015-000025
DP  - 2016 Feb 01
TA  - Journal of Investigative Medicine
PG  - 383--387
VI  - 64
IP  - 2
4099  - http://jim.bmj.com/content/64/2/383.short
4100  - http://jim.bmj.com/content/64/2/383.full
SO  - J Investig Med2016 Feb 01; 64
AB  - The relationship between triglyceridemia and diabetes mellitus remains unclear. This study evaluated the risk of diabetes and impaired fasting glucose associated with a wide range of triglyceride levels. A longitudinal retrospective study was carried out employing data from a screening center between the years 2000 and 2012. Inclusion criteria were absence of diabetes at baseline and attendance at the center at least twice over a 5-year period. Participants were divided by fasting blood glucose level (normal/impaired) at the first visit. A total of 5085 participants were eligible for the study. Of the 4164 normoglycemic participants at baseline, 40 (0.96%) had diabetes and 998 (24%) had impaired fasting glucose by the end of the study. On stepwise logistic regression analysis, every 10 mg/dL increase in triglyceride level significantly increased the risk of diabetes by 4% and of impaired fasting glucose by 2% (p<0.001). This association held true even when rising triglyceride levels remained within the accepted normal range (<150 mg/dL, p<0.001). Sustained increments in serum triglyceride level, even within the accepted normal range, are an independent risk factor for diabetes mellitus and impaired fasting glucose in normoglycemic participants.