TY - JOUR T1 - Vitamin-D status and mineral metabolism in two ethnic populations with sarcoidosis JF - Journal of Investigative Medicine JO - J Investig Med SP - 1025 LP - 1034 DO - 10.1136/jim-2016-000101 VL - 64 IS - 5 AU - Giovanna Capolongo AU - Li Hao Richie Xu AU - Mariasofia Accardo AU - Alessandro Sanduzzi AU - Anna Agnese Stanziola AU - Annamaria Colao AU - Carlo Agostini AU - Miriam Zacchia AU - Giovambattista Capasso AU - Beverley Adams-Huet AU - Orson W Moe AU - Naim M Maalouf AU - Khashayar Sakhaee AU - Connie C W Hsia Y1 - 2016/06/01 UR - http://hw-f5-jim.highwire.org/content/64/5/1025.abstract N2 - Vitamin-D insufficiency and sarcoidosis are more common and severe in African Americans (AA) than Caucasians. In sarcoidosis, substrate-dependent extrarenal 1,25-dihydroxyvitamin-D (1,25-(OH)2D) production is thought to contribute to hypercalciuria and hypercalcemia, and vitamin-D repletion is often avoided. However, the anti-inflammatory properties of vitamin-D may also be beneficial. We prospectively examined serum vitamin-D levels, calcium balance, and the effects of vitamin-D repletion in 86 AA and Caucasian patients with biopsy-proven active sarcoidosis from the USA (US) and Italy (IT) in university-affiliated outpatient clinics. Clinical features, pulmonary function, and calciotropic hormones were measured. 16 patients with vitamin-D deficiency and normal serum ionized calcium (Ca2+) were treated with oral ergocalciferol (50,000 IU/week) for 12 weeks. Baseline mineral parameters were similar in US (93% AA) and IT (95% Caucasian) patients irrespective of glucocorticoid treatment. Pulmonary dysfunction was less pronounced in IT patients. Nephrolithiasis (in 11% US, 17% IT patients) was associated with higher urinary calcium excretion. Vitamin-D deficiency was not more prevalent in patients compared to the respective general populations. As serum 25-hydroxyvitamin-D (25-OHD) rose postrepletion, serum 1,25-(OH)2D, γ-globulins, and the previously elevated angiotensin converting enzyme (ACE) levels declined. Asymptomatic reversible increases in Ca2+ or urinary calcium/creatinine (Ca/Cr) developed in three patients during repletion. In conclusion, Caucasian and AA patients show similar calcium and vitamin D profiles. The higher prevalence of hypercalciuria and nephrolithiasis in sarcoidosis is unrelated to endogenous vitamin-D levels. Vitamin-D repletion in sarcoidosis is generally safe, although calcium balance should be monitored. A hypothesis that 25-OHD repletion suppresses granulomatous immune activity is provided. ER -